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Programa de Mentores ISCIII. Publicaciones de los mentorizados 

Listado de publicaciones de los alumnos del Programa de Mentores del ISCIII.

Diagnostic Process in Rare Diseases: Determinants Associated with Diagnostic Delay 

Many people living with rare disease (RD) report a difficult diagnostic process from the symptom onset until they obtain the definitive diagnosis. The aim of this study was thus to ascertain the diagnostic process in RDs, and explore the determinants related with having to wait for more than one ye...

Educational Gradients in Drinking Amount and Heavy Episodic Drinking among Working-Age Men and Women in Spain 

Alcohol-related harm decreases as socioeconomic position increases, although sometimes the opposite happens with alcohol intake. The objective was to know the educational gradient in monthly measures of drinking amount and heavy episodic drinking (HED) among people aged 25-64 years in Spain from 19...

Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment 

We have observed a drug-tolerant/persister state in a human glioblastoma (GBM) cell line after exposure to temozolomide, the standard-of-care chemotherapeutic agent for GBM. We used a multicolor lentiviral genetic barcode labeling to follow cell population evolution during temozolomide treatment. W...

III Jornada Programa de Mentores del ISCIII 

La III Jornada del Programa de Mentores del ISCIII tuvo lugar el día 25 de abril de 2022. La jornada fue inaugurada por Miguel Calero Lara, Subdirector General de Servicios Aplicados, Formación e Investigación y presentadas por Lucía Pérez Álvarez, Coordinadora del Programa de Mentores del ISCIII.

II Jornada Programa de mentores del ISCIII 

La II Jornada del Programa de Mentores del ISCIII tuvo lugar el día 19 de octubre de 2021. Las jornadas fueron inauguradas por Miguel Calero Lara, Subdirector General de Servicios Aplicados, Formación e Investigación y presentadas por Lucía Pérez Álvarez Coordinadora del Programa de Mentores del IS...

I Jornada Programa de Mentores del ISCIII 

La I Jornada del Programa de Mentores del ISCIII tuvo lugar los días 19 y 20 de abril de 2021. Las jornadas fueron inauguradas por Raquel Yotti Álvarez, directora del ISCIII y presentadas por Lucía Pérez Álvarez, Coordinadora de Programa de la Subdirección General de Servicios Aplicados, Formació...

I Jornada de seminarios transversales 

Estás primeras jornadas se desarrollaron el 23 y 24 de mayo de 2022. Lucía Pérez, coordinadora del Progrma de Mentores, presentó el programa de las jornadas donde se trataron los siguientes temas: Consejos para la publicación científica (Ignacio Pérez de Castro (IIER), Mª José Buitrago (CNM), David...

Evolución de la mortalidad atribuible al alcohol en España según edad, sexo, causa de muerte y tipo de bebedor (2001-2017) 

[ES] En España no hay estimaciones recientes de la mortalidad atribuible a alcohol con datos de consumo de alcohol españoles. El objetivo es estimarla y conocer la evolución entre 2001 y 2017 en personas ≥15 años, según sexo, edad, periodo, causa de muerte y tipo de bebedor. Se utilizó el enfoque c...

Metodología utilizada para estimar la mortalidad atribuible a alcohol en España, 2001-2017 

[ES] El objetivo es describir y discutir los métodos y asunciones para estimar la mortalidad atribuible a alcohol en España en 2001-2017. Se estimó el nº medio anual de muertes atribuibles a alcohol (MAAs) basándose en 19 grupos de causas de muerte relacionadas con alcohol (18 parcialmente atribuib...

Effects of local factors on adaptation to heat in Spain (1983-2018) 

The European Union is currently immersed in policy development to address the effects of climate change around the world. Key plans and processes for facilitating adaptation to high temperatures and for reducing the adverse effects on health are among the most urgent measures. Therefore, it is nece...

Transgenesis in parasitic helminths: a brief history and prospects for the future 

Helminth infections impact the health of hundreds of millions of persons globally and also cause important economic losses in livestock farming. Methodological limitations as well as the low attention given to the study of helminths have impacted biological research and, thus, the procurement of ac...

RedLabRA; a Spanish Network of Microbiology Laboratories for the Surveillance of Antibiotic Resistant Microorganisms 

There is an urgent need to control the clinical and public health impact that antibiotic resistance (AR) causes worldwide. Any measure for its control must be based on an up-to-date and comprehensive knowledge of the situation. However, it is difficult to determine the current dimension of AR becau...

A genetic cluster of MDR Enterobacter cloacae complex ST78 harbouring a plasmid containing bla VIM-1 and mcr-9 in the Netherlands 

Background: Carbapenemases produced by Enterobacterales are often encoded by genes on transferable plasmids and represent a major healthcare problem, especially if the plasmids contain additional antibiotic resistance genes. As part of Dutch national surveillance, 50 medical microbiological laborat...

Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy 

The latent viral reservoir formed by HIV-1, mainly in CD4+ T cells, is responsible for the failure of antiretroviral therapy (ART) to achieve a complete elimination of the virus in infected individuals. We previously determined that CD4+ T cells from individuals with chronic myeloid leukemia (CML) ...

Cytotoxic cell populations developed during treatment with tyrosine kinase inhibitors protect autologous CD4+ T cells from HIV-1 infection 

Tyrosine kinase inhibitors (TKIs) are successfully used in clinic to treat chronic myeloid leukemia (CML). Our group previously described that CD4+ T cells from patients with CML on treatment with TKIs such as dasatinib were resistant to HIV-1 infection ex vivo. The main mechanism for this antivira...

The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes. 

Ewing sarcoma is a rare pediatric tumor characterized by chromosomal translocations that give rise to aberrant chimeric transcription factors (e.g., EWSR1-FLI1). EWSR1-FLI1 promotes a specific cellular transcriptional program. Therefore, the study of EWSR1-FLI1 target genes is important to identify...

Therapeutic Potential of EWSR1-FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma. 

Ewing sarcoma is an aggressive bone cancer affecting children and young adults. The main molecular hallmark of Ewing sarcoma are chromosomal translocations that produce chimeric oncogenic transcription factors, the most frequent of which is the aberrant transcription factor EWSR1-FLI1. Because this...

Sarcoma treatment in the era of molecular medicine. 

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More tha...

Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma 

Osteosarcoma is the most common malignant solid tumor that affects bones, however, survival rates of patients with relapsed osteosarcoma have not improved in the last 30 years. Oncolytic virotherapy, which uses viruses designed to selectively replicate in cancer cells, has emerged as a promising tr...