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Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

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URI: http://hdl.handle.net/20.500.12105/12456
DOI: 10.1016/j.jmii.2018.07.007

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2019-08

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Abstract

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.

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Exosomes miRNAs HIV-1 Elite controllers Immune activation Soluble biomarkers

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Exosomes Adult Biomarkers CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Chemokine CCL2 Cross-Sectional Studies Female HIV Infections HIV-1 Humans Male MicroRNAs Middle Aged Plasma

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J Microbiol Immunol Infect . 2019 Aug;52(4):667-671.

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Centro Nacional de Microbiología (CNM)
IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
IIS-FJD - Instituto de Investigación Sanitaria Fundación Jiménez Díaz (Madrid)
IRYCIS - Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)

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https://doi.org/10.1016/j.jmii.2018.07.007

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research article