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Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

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dc.contributor.authorRuiz-de-León, María J
dc.contributor.authorJimenez-Sousa, Maria Angeles
dc.contributor.authorMoreno, Santiago
dc.contributor.authorGarcía, Marcial
dc.contributor.authorGutiirrez-Rivas, Monica
dc.contributor.authorLeón, Agathe
dc.contributor.authorMontero-Alonso, Marta
dc.contributor.authorGonzález-García, Juan
dc.contributor.authorResino, Salvador
dc.contributor.authorRallón, Norma
dc.contributor.authorBenito, José Miguel
dc.contributor.authorVallejo, Alejandro
dc.contributor.authorECRIS Network integrated in the Spanish AIDS Research Network
dc.contributor.authorBriz, Veronica
dc.contributor.authorVázquez-Morón, Sonia
dc.contributor.authorFernández, A
dc.contributor.authorGarcía, P
dc.contributor.authorPernas, Maria
dc.contributor.authorCasado, Concepcion
dc.contributor.authorLópez, C
dc.contributor.authorCapa, Laura
dc.contributor.authorPérez, M
dc.contributor.authorAlcamí, José
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderRed de Investigación Cooperativa en Investigación en Sida (España)
dc.contributor.funderComunidad de Madrid (España)
dc.date.accessioned2021-03-27T15:02:59Z
dc.date.available2021-03-27T15:02:59Z
dc.date.issued2019-08
dc.description.abstractExosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work has been partially funded by the Spanish Health Institute Carlos III (ISCIII) and European Regional Development Fund, Spanish AIDS Research Network (RIS) with grant numbers RD16/0025/0001, RD12/0017/0031, RD16/0025/0013, and RD16/0002/0002. Research Grant Project, Spanish Health Research Fund (FIS, ISCIII) number PI14/00011. Miguel Servet Research Program, Spanish Health Institute Carlos III (ISCIII) CP14/00198 to NR. Spanish Health Research Fund (FIS, ISCIII) and IIS-FJD Intramural Research Scholarship co-funded grant number CP14/00198 to MG. Spanish Health Institute Carlos III (ISCIII) grant CD13/00013 to MAJS. Grant Research, Madrid Education, Youth and Sport Counseling number PEJ15/bio/tl-0064 to MJRL.es_ES
dc.format.number4es_ES
dc.format.page667-671es_ES
dc.format.volume52es_ES
dc.identifier.citationJ Microbiol Immunol Infect . 2019 Aug;52(4):667-671.es_ES
dc.identifier.doi10.1016/j.jmii.2018.07.007es_ES
dc.identifier.e-issn1995-9133es_ES
dc.identifier.journalJournal of microbiology, immunology, and infection = Wei mian yu gan ran za zhies_ES
dc.identifier.pubmedID30193823es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12456
dc.language.isoenges_ES
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0025/0001es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0017/0031es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0025/0013,es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0002/0002es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP14/00198es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD13/00013es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jmii.2018.07.007es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectExosomeses_ES
dc.subjectmiRNAses_ES
dc.subjectHIV-1es_ES
dc.subjectElite controllerses_ES
dc.subjectImmune activationes_ES
dc.subjectSoluble biomarkerses_ES
dc.subject.meshExosomeses_ES
dc.subject.meshAdultes_ES
dc.subject.meshBiomarkerses_ES
dc.subject.meshCD4 Lymphocyte Countes_ES
dc.subject.meshCD4-Positive T-Lymphocyteses_ES
dc.subject.meshChemokine CCL2es_ES
dc.subject.meshCross-Sectional Studieses_ES
dc.subject.meshFemalees_ES
dc.subject.meshHIV Infectionses_ES
dc.subject.meshHIV-1es_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMicroRNAses_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshPlasmaes_ES
dc.titleLower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell countes_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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Centro Nacional de Microbiología (CNM)
IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
IIS-FJD - Instituto de Investigación Sanitaria Fundación Jiménez Díaz (Madrid)
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