Publication: Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility
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Mellado, Emilia ISCIII 
Garcia-Effron, Guillermo ISCIII
Buitrago, Maria Jose ISCIII
Alcazar-Fuoli, Laura ISCIII
Cuenca-Estrella, Manuel ISCIII
Rodriguez-Tudela, Juan Luis ISCIII
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American Society for Microbiology (ASM)
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Abstract
The role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice.
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Antimicrob Agents Chemother. 2005;49(6):2536-8.