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Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility

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dc.contributor.authorMellado, Emilia
dc.contributor.authorGarcia-Effron, Guillermo
dc.contributor.authorBuitrago, Maria Jose
dc.contributor.authorAlcazar-Fuoli, Laura
dc.contributor.authorCuenca-Estrella, Manuel
dc.contributor.authorRodriguez-Tudela, Juan Luis
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)
dc.date.accessioned2019-05-31T10:32:26Z
dc.date.available2019-05-31T10:32:26Z
dc.date.issued2005-06
dc.description.abstractThe role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported in part by grants MPY1120/03 from Instituto de Salud Carlos III and SAF2002-02089 from the Ministry of Science and Technology. E. Mellado held a Ramo´n y Cajal contract from the Ministry of Science and Technology. L. Alcazar-Fuoli has a predoctoral fellowship from the Instituto de Salud Carlos III.es_ES
dc.format.number6es_ES
dc.format.page2536-8es_ES
dc.format.volume49es_ES
dc.identifier.citationAntimicrob Agents Chemother. 2005;49(6):2536-8.es_ES
dc.identifier.doi10.1128/AAC.49.6.2536-2538es_ES
dc.identifier.issn0066-4804es_ES
dc.identifier.journalAntimicrobial agents and chemotherapyes_ES
dc.identifier.pubmedID15917566es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7702
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiology (ASM)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MPY1120/03es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2002-02089es_ES
dc.relation.publisherversionhttps://doi.org/10.1128/AAC.49.6.2536-2538.2005es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleTargeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibilityes_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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