TY - JOUR AU - Mellado, Emilia AU - Garcia-Effron, Guillermo AU - Buitrago, Maria Jose AU - Alcazar-Fuoli, Laura AU - Cuenca-Estrella, Manuel AU - Rodriguez-Tudela, Juan Luis PY - 2005 DO - 10.1128/AAC.49.6.2536-2538 SN - 0066-4804 UR - http://hdl.handle.net/20.500.12105/7702 AB - The role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were... LA - eng PB - American Society for Microbiology (ASM) TI - Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility TY - journal article ER -