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Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine.

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URI: http://hdl.handle.net/20.500.12105/17472
DOI: 10.1002/adma.201304428

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2014-05-21

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Abstract

MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.

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Regenerative Medicine Tissue Engineering Acrylic Resins Cell Line Collagen Dextran Sulfate Extracellular Matrix Fibroblasts Humans Macromolecular Substances Matrix Metalloproteinase 2

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Adv Mater. 2014 ;26(19):3024-34.

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journal article