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New species genetic approach to identify strains of mitis group streptococci that are donors of rifampin resistance to Streptococcus pneumoniae

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URI: http://hdl.handle.net/20.500.12105/8709
ISSN: 0066-4804
DOI: 10.1128/AAC.00856-10

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2011-01

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American Society for Microbiology (ASM)
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Eight rifampin-resistant streptococci of the mitis group were identified at the species level by using a concatenated 16S rRNA gene-sodA-rpoB-hlpA sequence. Characterization of their rpoB alleles showed single amino acid changes involved in rifampin resistance. Comparison of RpoB sequences from pneumococcal recombinant isolates, viridans isolates, and type strains revealed a species-specific amino acid signature, which allowed it to be ascertained that recombinant RpoBs were originated in genetic interchanges with Streptococcus mitis and Streptococcus oralis.

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Anti-Bacterial Agents Drug Resistance, Bacterial Phylogeny RNA, Ribosomal, 16S Rifampin Streptococcus mitis Streptococcus oralis Streptococcus pneumoniae

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Antimicrob Agents Chemother. 2011 Jan;55(1):368-72. doi: 10.1128/AAC.00856-10. Epub 2010 Nov 1.

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Centro Nacional de Microbiología (CNM)

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https://doi.org/10.1128/AAC.00856-10

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journal article