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Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan.

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URI: https://hdl.handle.net/20.500.12105/27171
DOI: 10.3201/eid2901.220775

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2023-01

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Pfhrp2 and pfhrp3 gene deletions threaten the use of Plasmodium falciparum malaria rapid diagnostic tests globally. In South Sudan, deletion frequencies were 15.6% for pfhrp2, 20.0% for pfhrp3, and 7.5% for double deletions. Deletions were approximately twice as prevalent in monoclonal infections than in polyclonal infections.

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Plasmodium falciparum RDT South Sudan Diagnosis Histidine-rich protein Malaria Molecular epidemiology Parasites Surveillance Vector-borne infections

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Molina-de la Fuente I, Benito MJS, Flevaud L, Ousley J, Pasquale HA, Julla A, Abdi AM, Chol BT, Abubakr B, Benito A, Casademont C, Nanclares C, Berzosa P. Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan. Emerg Infect Dis. 2023 Jan;29(1):154-159. doi: 10.3201/eid2901.220775. PMID: 36573593; PMCID: PMC9796199.

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Centro Nacional de Medicina Tropical (CNMT)

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https://doi.org/10.3201/eid2901.220775

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research article