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CRISPR activation to repair electrocardiogram abnormalities caused by a FLNC truncating variant in mice.

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dc.contributor.authorCañas-Alvaro, Rodrigo
dc.contributor.authorLalaguna, Laura
dc.contributor.authorRubio, Blanca
dc.contributor.authorAusiello, Antonella
dc.contributor.authorLópez-Olañeta, Marina
dc.contributor.authorSerrano-Blanco, Rocío F
dc.contributor.authorOchoa, Juan Pablo
dc.contributor.authorde la Pompa, Jose Luis
dc.contributor.authorChavez, Alejandro
dc.contributor.authorGarcía-Pavía, Pablo
dc.contributor.authorLara-Pezzi, Enrique
dc.date.accessioned2025-12-10T18:05:31Z
dc.date.available2025-12-10T18:05:31Z
dc.date.issued2025-11-14
dc.description.peerreviewedSí
dc.description.tableofcontentsThis project was funded by the Pathfinder Cardiogenomics programme of the European Innovation Council of the European Union (DCM-NEXT project; project number: 101115416) to E.L.-P. and P.G.-P. and grants PID2021-124629OB-I00, TED2021-129774B-C22, and PLEC2022-009235 funded by the Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033), by the European Union’s NextGenerationEU/PRTR (‘Plan de Recuperación, Transformación y Resiliencia de España’) and by FEDER to E.L.-P. and grants PID2022-136942OB-I00, CB16/11/00399 (CIBER CV) from MICIU/AEI/10.13039/501100011033, and La Caixa Research Health Foundation (HR23-00084) to J.L.d.l.P. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MICIU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033). A.C. was supported by NIH Grant DP2NS131566-01 and a Career Award for Medical Scientists from the Burroughs Wellcome Foundation.
dc.format.number43
dc.format.page4610-4613
dc.format.volume46
dc.identifier.citationEur Heart J. 2025 Nov 14;46(43):4610-4613.
dc.identifier.doihttps://doi.org/10.1093/eurheartj/ehaf703
dc.identifier.pubmedID40886060
dc.identifier.urihttps://hdl.handle.net/20.500.12105/27007
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS
dc.relation.isreferencedbyPubMed
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2021-124629OB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/TED2021-129774B-C22
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PLEC2022-00923
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/HR23-00084
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CEX2020-001041-S
dc.relation.publisherversionEUROPEAN HEART JOURNAL
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiaca
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCRISPR activation
dc.subjectCardiomyopathy
dc.subjectDilated cardiomyopathy
dc.subjectFLNC truncating variants
dc.subjectGene therapy
dc.subjectNon-dilated left ventricular cardiomyopathy
dc.titleCRISPR activation to repair electrocardiogram abnormalities caused by a FLNC truncating variant in mice.
dc.typeeditorial
dc.type.hasVersionVoR
dspace.entity.typePublication

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