Publication: Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
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2024-02-19
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Nature Publishing Group
Abstract
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.
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Commun Biol. 2024 Feb 19;7(1):202.
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Centro Nacional de Microbiología (CNM)
i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)
IBIS - Instituto de Biomedicina de Sevilla (Andalucía)
ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
IBSAL - Instituto de Investigación Biómedica de Salamanca (Castilla y León)
IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
Load more i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)
IBIS - Instituto de Biomedicina de Sevilla (Andalucía)
ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
IBSAL - Instituto de Investigación Biómedica de Salamanca (Castilla y León)
IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)