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Is liver regeneration key in hepatocellular carcinoma development?

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dc.contributor.authorRigual, María Del Mar
dc.contributor.authorSánchez Sánchez, Paula
dc.contributor.authorDjouder, Nabil
dc.contributor.funderFundación BBVA
dc.contributor.funderMinisterio de Ciencia (España)
dc.date.accessioned2024-02-09T09:08:03Z
dc.date.available2024-02-09T09:08:03Z
dc.date.issued2023-02
dc.description.abstractThe liver is the largest organ of the mammalian body and has the remarkable ability to fully regenerate in order to maintain tissue homeostasis. The adult liver consists of hexagonal lobules, each with a central vein surrounded by six portal triads localized in the lobule border containing distinct parenchymal and nonparenchymal cells. Because the liver is continuously exposed to diverse stress signals, several sophisticated regenerative processes exist to restore its functional status following impairment. However, these stress signals can affect the liver's capacity to regenerate and may lead to the development of hepatocellular carcinoma (HCC), one of the most aggressive liver cancers. Here, we review the mechanisms of hepatic regeneration and their potential to influence HCC development.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was funded by grants to N.D. from the Comunidad Autonoma de Madrid (S2017/BMD-3817) and from the State Research Agency (AEI, 10.13039/501100011033) , from the Spanish Ministry of Science and Innovation (projects RTI2018-094834-B-I00 and PID2021-122695OB-I00) , cofunded by European Regional Development Fund (ERDF) , by the BBVA foundation grants for biomedicine (project EIC21-1-243) , and by the Asociacion Espanola Contra el Cancer (AECC) (project PRYGN211184DJOU) . M.d.M.R. and P.S. are respectively supported by fellowships from FPI-Severo Ochoa and FPI from the Spanish Ministry of Science and Innovation. This work was developed at the CNIO funded by the Health Institute Carlos III (ISCIII) and the Spanish Ministry of Science and Innovation.es_ES
dc.format.number2es_ES
dc.format.page140es_ES
dc.format.volume9es_ES
dc.identifier.citationTrends Cancer . 2023 ;9(2):140-157es_ES
dc.identifier.doi10.1016/j.trecan.2022.10.005es_ES
dc.identifier.e-issn2405-8025es_ES
dc.identifier.journalTrends in canceres_ES
dc.identifier.pubmedID36347768es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17679
dc.language.isoenges_ES
dc.publisherCell Press
dc.relation.publisherversionhttps://doi.org/10.1016/j.trecan.2022.10.005.es_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Factores de Crecimiento, Nutrientes y Cánceres_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshCarcinoma, Hepatocellulares_ES
dc.subject.meshLiver Neoplasmses_ES
dc.subject.meshAdultes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshHumanses_ES
dc.subject.meshHepatocyteses_ES
dc.subject.meshLiver Regenerationes_ES
dc.subject.meshMammalses_ES
dc.titleIs liver regeneration key in hepatocellular carcinoma development?es_ES
dc.typejournal articlees_ES
dc.type.hasVersionAMes_ES
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