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An unexpected role for PD-L1 in front-rear polarization and directional migration.

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URI: http://hdl.handle.net/20.500.12105/16740
DOI: 10.1083/jcb.202203137
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2022-05-02
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Rockefeller University Press
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Programmed cell death-ligand 1 (PD-L1)-mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front-rear polarity and directionally persistent cell migration, independently of PD-1.
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B7-H1 Antigen Neoplasms Cell Movement Humans Programmed Cell Death 1 Receptor T-Lymphocytes Tumor Escape
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J Cell Biol. 2022 May 2;221(5):e202203137.
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10.1083/jcb.202203137
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editorial