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Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.

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dc.contributor.authorMallorquí-Bagué, Núria
dc.contributor.authorLozano-Madrid, María
dc.contributor.authorToledo, Estefanía
dc.contributor.authorCorella, Dolores
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorCuenca-Royo, Aida
dc.contributor.authorVioque, Jesús
dc.contributor.authorRomaguera, Dora
dc.contributor.authorMartínez, J Alfredo
dc.contributor.authorWärnberg, Julia
dc.contributor.authorLópez-Miranda, José
dc.contributor.authorEstruch, Ramón
dc.contributor.authorBueno-Cavanillas, Aurora
dc.contributor.authorAlonso-Gómez, Ángel
dc.contributor.authorTur, Josep A
dc.contributor.authorTinahones, Francisco J
dc.contributor.authorSerra-Majem, Lluís
dc.contributor.authorMartín, Vicente
dc.contributor.authorLapetra, José
dc.contributor.authorVázquez, Clotilde
dc.contributor.authorPintó, Xavier
dc.contributor.authorVidal, Josep
dc.contributor.authorDaimiel, Lidia
dc.contributor.authorGaforio, José J
dc.contributor.authorMatía, Pilar
dc.contributor.authorRos, Emilio
dc.contributor.authorGranero, Roser
dc.contributor.authorBuil-Cosiales, Pilar
dc.contributor.authorBarragán, Rocío
dc.contributor.authorBulló, Mònica
dc.contributor.authorCastañer, Olga
dc.contributor.authorGarcía-de-la-Hera, Manoli
dc.contributor.authorYáñez, Aina M
dc.contributor.authorAbete, Itziar
dc.contributor.authorGarcía-Ríos, Antonio
dc.contributor.authorRuiz-Canela, Miguel
dc.contributor.authorDíaz-López, Andrés
dc.contributor.authorJiménez-Murcia, Susana
dc.contributor.authorMartínez-González, Miguel A
dc.contributor.authorDe la Torre, Rafael
dc.contributor.authorFernández-Aranda, Fernando
dc.date.accessioned2024-02-08T14:41:57Z
dc.date.available2024-02-08T14:41:57Z
dc.date.issued2018-10-31
dc.description.abstractThis study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c
dc.description.sponsorshipWe thank the PREDIMED-PLUS Biobank Network, as a part of the National Biobank Platform of the Carlos III Health Institute (ISCIII) for storing and managing the PREDIMED-PLUS biological samples. Contract Juan Rodes from the Instituto de Salud Carlos III to Olga Castaner (JR17/00022) is duly acknowledged. This project is funded by Instituto de Salud Carlos III (ISCIII), the Spanish Government Official Agency for funding biomedical research - with competitive grants for the periods 2014-2016, 2015-2017, 2017-2019 and 2018-2020, through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund [grants: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728 PI13/01090 PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926] and the European Research Council [Advanced Research Grant 2014-2019; agreement #340918]. Additional grants: Acciones Especiales from ISCIIII, Consejeria-Salud, Junta -Andalucia [PI0458/2013, PS0358/2016], Recercaixa-grant 2013 [2013ACUP00194], a SEMERGEN grant, International Nut & Dried Fruit Council - FESNAD No. 201302. Fundacion Patrimonio Comunal Olivarero is providing the necessary amounts of olive oil. Nuts were initially and only partially provided by Pistachios Growers and Almond Board of California, for the pilot study. This research was also partially funded by EU-H2020 Grant (Eat2beNICE/H2020-SFS-2016-2; Ref 728018), PI14/00290 y PI17/1167(Co-funded by European Regional Development Fund, ERDF, a way to build Europe), PERIS (Generalitat de Catalunya, SLT006/17/00077), Grant PROMETEO/2017/017 (Generalitat Valenciana) and Grant FEA/SEA 2017 for Primary Care Research. We thank CERCA Programme/Generalitat de Catalunya for institutional support. ML-M is supported by a predoctoral Grant of the Ministerio de Educacion, Cultura y Deporte (FPU15/02911). None of these funding sources plays any role in the design, collection, analysis, or interpretation of the data or in the decision to submit manuscripts for publication.
dc.format.number1es_ES
dc.format.page16128es_ES
dc.format.volume8es_ES
dc.identifier.doi10.1038/s41598-018-33843-8
dc.identifier.e-issn2045-2322es_ES
dc.identifier.journalScientific reportses_ES
dc.identifier.otherhttp://hdl.handle.net/10668/13146
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/9064
dc.identifier.pubmedID30382190es_ES
dc.identifier.puiL624724993
dc.identifier.scopus2-s2.0-85055818232
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17637
dc.identifier.wos448814600026
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.publisherversionhttps://dx.doi.org/10.1038/s41598-018-33843-8
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.decsÍndice de Masa Corporal
dc.subject.decsDisfunción Cognitiva
dc.subject.decsEstudios Transversales
dc.subject.decsHumanos
dc.subject.decsPersona de Mediana Edad
dc.subject.decsObesidad
dc.subject.decsSíndrome Metabólico
dc.subject.decsAnciano
dc.subject.decsDiabetes Mellitus Tipo 2
dc.subject.decsFemenino
dc.subject.decsHemoglobina A Glucada
dc.subject.decsMasculino
dc.subject.meshAged
dc.subject.meshBody Mass Index
dc.subject.meshCognitive Dysfunction
dc.subject.meshCross-Sectional Studies
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshFemale
dc.subject.meshGlycated Hemoglobin
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMetabolic Syndrome
dc.subject.meshMiddle Aged
dc.subject.meshObesity
dc.titleType 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isPublisherOfPublication301fb00e-338e-4f8c-beaa-f9d8f4fefcc0
relation.isPublisherOfPublication.latestForDiscovery301fb00e-338e-4f8c-beaa-f9d8f4fefcc0

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IBIMA-Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (Andalucía)
IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
IdISSC - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (Madrid)
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