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Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and mutation.

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dc.contributor.authorGarcía-Silva, Susana
dc.contributor.authorBenito-Martín, Alberto
dc.contributor.authorSánchez-Redondo, Sara
dc.contributor.authorHernández-Barranco, Alberto
dc.contributor.authorXiménez-Embún, Pilar
dc.contributor.authorNogués, Laura
dc.contributor.authorMazariegos, Marina S
dc.contributor.authorBrinkmann, Kay
dc.contributor.authorAmor López, Ana
dc.contributor.authorMeyer, Lisa
dc.contributor.authorRodríguez, Carlos
dc.contributor.authorGarcía-Martín, Carmen
dc.contributor.authorBoskovic, Jasminka
dc.contributor.authorLetón, Rocío
dc.contributor.authorMontero, Cristina
dc.contributor.authorRobledo Batanero, Mercedes
dc.contributor.authorSantambrogio, Laura
dc.contributor.authorSue Brady, Mary
dc.contributor.authorSzumera-Ciećkiewicz, Anna
dc.contributor.authorKalinowska, Iwona
dc.contributor.authorSkog, Johan
dc.contributor.authorNoerholm, Mikkel
dc.contributor.authorMuñoz, Javier
dc.contributor.authorOrtiz-Romero, Pablo L
dc.contributor.authorRuano, Yolanda
dc.contributor.authorRodríguez-Peralto, José L
dc.contributor.authorRutkowski, Piotr
dc.contributor.authorPeinado Selgas, Hector
dc.contributor.funderUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA
dc.contributor.funderFeldstein Foundation
dc.contributor.funderStarr Cancer Consortium
dc.contributor.funderLa Caixa Foundation
dc.contributor.funderFundacion Cientifica Asociacion Espanola Contra el Cancer
dc.contributor.funderRamon Areces Foundation
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderMinisterio de Ciencia y Competetividad (España)
dc.date.accessioned2025-01-07T17:05:53Z
dc.date.available2025-01-07T17:05:53Z
dc.date.issued2019-05-06
dc.descriptionThis work was supported by the US National Institutes of Health (R01-CA169416), the Feldstein Foundation, the Starr Cancer Consortium, Ministerio de Economia y Competitividad, the Ramon y Cajal Program, Atresmedia-Fundacion AXA, "La Caixa" Foundation (ID 100010434, Fellowship LCF/BQ/ES17/11600007), Fundacion Cientifica Asociacion Espanola Contra el Cancer, Fundacion de Investigacion Oncologica, Ministerio de Economia y Competitividad-Red de Excelencia en Investigacion e Innovacion en Exosomas, the Ramon Areces Foundation, and Comunidad Autonoma de Madrid.
dc.description.abstractLiquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.
dc.description.peerreviewedSí
dc.format.number5
dc.format.page1061-1070
dc.format.volume216
dc.identifier.citationJ Exp Med . 2019 May 6;216(5):1061-1070.
dc.identifier.journalJournal of Experimental Medicine
dc.identifier.pubmedID30975894
dc.identifier.urihttps://hdl.handle.net/20.500.12105/25958
dc.language.isoeng
dc.publisherRockefeller University Press
dc.relation.publisherversionhttp:// 10.1084/jem.20181522
dc.repisalud.institucionCNIO
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Microambiente y Metástasis
dc.rights.accessRightsopen access
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMUTANT KRAS
dc.subjectEXOXOME
dc.subjectDNA CELLS
dc.titleUse of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and mutation.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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relation.isAuthorOfPublicatione5c716e0-8396-45cb-a653-686569945266
relation.isAuthorOfPublicationf33d0f5a-ce2e-4874-a2d8-03c0974e8b1d
relation.isAuthorOfPublication.latestForDiscovery400c30f1-1f41-4b0d-8b2e-327d5b9c3e7e

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