Publication: Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and mutation.
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Rockefeller University Press
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Abstract
Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.
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This work was supported by the US National Institutes of Health (R01-CA169416), the Feldstein Foundation, the Starr Cancer Consortium, Ministerio de Economia y Competitividad, the Ramon y Cajal Program, Atresmedia-Fundacion AXA, "La Caixa" Foundation (ID 100010434, Fellowship LCF/BQ/ES17/11600007), Fundacion Cientifica Asociacion Espanola Contra el Cancer, Fundacion de Investigacion Oncologica, Ministerio de Economia y Competitividad-Red de Excelencia en Investigacion e Innovacion en Exosomas, the Ramon Areces Foundation, and Comunidad Autonoma de Madrid.
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J Exp Med . 2019 May 6;216(5):1061-1070.