Publication:
Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria

Simple item page
dc.contributor.authorde la Cuesta, Fernando
dc.contributor.authorBaldan-Martin, Montserrat
dc.contributor.authorMoreno-Luna, Rafael
dc.contributor.authorAlvarez-Llamas, Gloria
dc.contributor.authorGonzalez-Calero, Laura
dc.contributor.authorMourino-Alvarez, Laura
dc.contributor.authorSastre-Oliva, Tamara
dc.contributor.authorLopez, Juan Antonio
dc.contributor.authorVazquez, Jesus
dc.contributor.authorRuiz-Hurtado, Gema
dc.contributor.authorSegura, Julian
dc.contributor.authorVivanco, Fernando
dc.contributor.authorRuilope, Luis M
dc.contributor.authorBarderas, Maria G
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderIDC Salud
dc.contributor.funderFundación Mutua Madrileña
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.date.accessioned2017-10-20T10:33:49Z
dc.date.available2017-10-20T10:33:49Z
dc.date.issued2017
dc.description.abstractDespite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin-System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies. Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs. In vitro analysis using TNFa-treated adult human endothelial cells proved their involvement in endothelial cell activation. Hence, we propose protein levels of kalirin and CHD7 in circulating EVs as novel endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria.
dc.description.peerreviewedSí
dc.description.sponsorshipThis work was supported by grants from the Instituto de Salud Carlos III (PI070537, IF08/3667-1, PI1102239, PI 14/0917, PI11/01401, PI11/02432, PI13/01873, PI13/01746, PI13/01581, PI14/01650, PI14/01841), PT13/0001/0013 ,PIE13/00051, PIE13/00045, CP09/00229, IDCSalud(3371/002), Fundacion Mutua Madrilena, Fundacion Conchita Rabago de Jimenez Diaz and FONDOS FEDER (RD06/0014/1015 ,RD12/0042/0071). These results are lined up with the Spanish initiative on the Human Proteome Project.
dc.format.page15553-15562
dc.format.volume8
dc.identifierISI:000396013700108
dc.identifier.citationOncotarget. 2017; 8(9):15553-15562
dc.identifier.doi10.18632/oncotarget.14948
dc.identifier.issn1949-2553
dc.identifier.journalOncotarget
dc.identifier.pubmedID28152519
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5161
dc.language.isoeng
dc.publisherImpact Journals
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI07/0537es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/IF08/3667-1es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02239es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/0917es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01401es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02432es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/01873es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/01746es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/01581es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01650es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/01841es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PT13/0001/0013es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIE13/00051es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIE13/00045es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CP09/00229es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD06/0014/1015es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD12/0042/0071es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/oncotarget.14948
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovascular
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómica
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectExtracellular vesicles
dc.subjectProteomics
dc.subjectEndothelial dysfunction
dc.subjectHypertension
dc.subjectAlbuminuria
dc.subjectANGIOTENSIN SYSTEM SUPPRESSION
dc.subjectOXIDATIVE STRESS
dc.subjectCELLS
dc.subjectMICROALBUMINURIA
dc.subjectDISEASE
dc.titleKalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationd79f2bf1-6f13-4b5f-9ae3-4c0ea06e9dcb
relation.isAuthorOfPublication9743763b-919c-4fa9-a53c-57c41be5e0ac
relation.isAuthorOfPublication.latestForDiscoveryd79f2bf1-6f13-4b5f-9ae3-4c0ea06e9dcb

Files

Original bundle

Now showing 1 - 3 of 3
Thumbnail Image
Name:
KalirinAndCHD7Novel_2017
Size:
10.25 MB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
KalirinAndCHD7Novel_2017_suppl1
Size:
1.6 MB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
KalirinAndCHD7Novel_2017_suppl2
Size:
4.19 MB
Format:
Microsoft Excel XML
Download

Collections

Grupos de investigación
Servicios de apoyo a la investigación