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Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

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dc.contributor.authorInformal Expert Group on Gambiense HAT Reservoirs
dc.contributor.authorBüscher, Philippe
dc.contributor.authorBart, Jean Mathieu
dc.contributor.authorBoelaert, Marleen
dc.contributor.authorBucheton, Bruno
dc.contributor.authorCecchi, Giuliano
dc.contributor.authorChitnis, Nakul
dc.contributor.authorCourtin, David
dc.contributor.authorFigueiredo, Luisa M
dc.contributor.authorFranco, José-Ramon
dc.contributor.authorGrébaut, Pascal
dc.contributor.authorHasker, Epco
dc.contributor.authorIlboudo, Hamidou
dc.contributor.authorJamonneau, Vincent
dc.contributor.authorKoffi, Mathurin
dc.contributor.authorLejon, Veerle
dc.contributor.authorMacLeod, Annette
dc.contributor.authorMasumu, Justin
dc.contributor.authorMatovu, Enock
dc.contributor.authorMattioli, Raffaele
dc.contributor.authorNoyes, Harry
dc.contributor.authorPicado, Albert
dc.contributor.authorRock, Kat S
dc.contributor.authorRotureau, Brice
dc.contributor.authorSimo, Gustave
dc.contributor.authorThévenon, Sophie
dc.contributor.authorTrindade, Sandra
dc.contributor.authorTruc, Philippe
dc.contributor.authorVan Reet, Nick
dc.contributor.funderFood and Agriculture Organization of the United Nations
dc.contributor.funderFundação para a Ciência e Tecnologia (Portugal)
dc.contributor.funderThe Task Force for Global Health
dc.contributor.funderBill & Melinda Gates Foundation
dc.contributor.funderGovernment of Italyes_ES
dc.contributor.funderWellcome Trust
dc.date.accessioned2022-03-30T08:25:46Z
dc.date.available2022-03-30T08:25:46Z
dc.date.issued2018-03
dc.description.abstractTrypanosoma brucei gambiense causes human African trypanosomiasis (HAT). Between 1990 and 2015, almost 440000 cases were reported. Large-scale screening of populations at risk, drug donations, and efforts by national and international stakeholders have brought the epidemic under control with <2200 cases in 2016. The World Health Organization (WHO) has set the goals of gambiense-HAT elimination as a public health problem for 2020, and of interruption of transmission to humans for 2030. Latent human infections and possible animal reservoirs may challenge these goals. It remains largely unknown whether, and to what extend, they have an impact on gambiense-HAT transmission. We argue that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by a grant from the Bill & Melinda Gates Foundation ( OPP1150674 ). KSR gratefully acknowledges funding of the NTD Modelling Consortium by the Bill & Melinda Gates Foundation in partnership with the Task Force for Global Health under grant number OPP1053230 . AML, BB, EM, GS, HI, MK, VJ, and VL are supported by TrypanoGen funded by the Wellcome Trust (grant number 099310/Z/12/Z ). NC acknowledges funding from the Bill & Melinda Gates Foundation under grant OPP1156227 . LMF is funded by Fundacao para a Ciencia e Tecnologia ( IF/01050/2014 ). FAO contribution to this study was provided in the framework of the Programme against African Trypanosomosis (PAAT), and supported by the Government of Italy (FAO Project ‘Improving food security in sub-Saharan Africa by supporting the progressive reduction of tsetse-transmitted trypanosomosis in the framework of the NEPAD’, codes GTFS/RAF/474/ITA and GCP/RAF/502/ITA). The funders had no role in design, decision to publish, or preparation of the manuscript. The views, opinions, assumptions or any other information set out in this article are solely those of the authors.es_ES
dc.format.number3es_ES
dc.format.page197-207es_ES
dc.format.volume34es_ES
dc.identifier.citationTrends Parasitol. 2018;34(3):197-207.es_ES
dc.identifier.doi10.1016/j.pt.2017.11.008es_ES
dc.identifier.e-issn1471-5007es_ES
dc.identifier.journalTrends in Parasitologyes_ES
dc.identifier.pubmedID29396200es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13902
dc.language.isoenges_ES
dc.publisherCell Press
dc.relation.publisherversionhttps://doi.org/10.1016/j.pt.2017.11.008es_ES
dc.repisalud.centroISCIII::Centro Nacional de Medicina Tropical (CNMT)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTrypanosoma brucei gambiensees_ES
dc.subjectEliminationes_ES
dc.subjectHuman African trypanosomiasises_ES
dc.subjectReservoires_ES
dc.subjectSleeping sickness.es_ES
dc.subjectTransmissiones_ES
dc.subject.meshDisease Eradicationes_ES
dc.subject.meshDisease Reservoirses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshHumanses_ES
dc.subject.meshRisk Factorses_ES
dc.subject.meshTrypanosoma brucei gambiensees_ES
dc.subject.meshTrypanosomiasis, Africanes_ES
dc.titleDo Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?es_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
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