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Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira

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Abstract

Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease's treatment and diagnosis.

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Crainey JL, Costa CHA, de Oliveira Leles LF, Ribeiro da Silva TR, de Aquino Narzetti LH, Serra Dos Santos YV, Costa Conteville L, Costa Pessoa FA, Carvajal Cortés JJ, Vicente ACP, Rubio Muñoz JM, Bessa Luz SL. Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira. Clin Infect Dis. 2020 Nov 5;71(8):1990-1993.

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