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MitoBlue as a tool to analyze the mitochondria-lysosome communication

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URI: http://hdl.handle.net/20.500.12105/18006
DOI: 10.1038/s41598-020-60573-7
Full text access: http://hdl.handle.net/10668/3856

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2020-02-26

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MitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial dyes and recombinant fluorescent probes, allowing the dynamic study of mitochondrial recycling in a variety of situations in living cells. MitoBlue is a unique tool for the study of these processes that will allow the detailed characterization of communication between mitochondria and lysosomes.

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Mitochondrial degradation Lysosome Microscopy Mitochondria Proteins Quality control Mitofagia Lisosomas Microscopía Mitocondrias Proteínas Control de calidad

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2-Naphthylamine Amidines Animals Chick Embryo Fibroblasts Lysosomes Microscopy, Fluorescence Mitochondria Fluorescent Dyes

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IBIMA-Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (Andalucía)

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https://www.nature.com/articles/s41598-020-60573-7

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research article