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dc.contributor.authorGago-Lopez, Nuria
dc.contributor.authorMellor, Liliana F
dc.contributor.authorMegias Vazquez, Diego 
dc.contributor.authorMartín-Serrano, Guillermo
dc.contributor.authorIzeta, Ander
dc.contributor.authorJimenez, Francisco
dc.contributor.authorWagner, Erwin Friedrich
dc.identifier.citationEMBO Mol Med. 2019;11(11):e10697.es_ES
dc.description.abstractPsoriasis is a common inflammatory skin disease involving a cross-talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF-SCs) in psoriasis is not well defined. Here, we show reduced expression of c-JUN and JUNB in bulge HF-SCs in patients with scalp psoriasis. Using lineage tracing in mouse models of skin inflammation with inducible deletion of c-Jun and JunB, we found that mutant bulge HF-SCs initiate epidermal hyperplasia and skin inflammation. Mechanistically, thymic stromal lymphopoietin (TSLP) was identified in mutant cells as a paracrine factor stimulating proliferation of neighboring non-mutant epidermal cells, while mutant inter-follicular epidermal (IFE) cells are lost over time. Blocking TSLP in psoriasis-like mice reduced skin inflammation and decreased epidermal proliferation, VEGFα expression, and STAT5 activation. These findings unravel distinct roles of HF-SCs and IFE cells in inflammatory skin disease and provide novel mechanistic insights into epidermal cell interactions in inflammation.es_ES
dc.description.sponsorshipWe thank Drs. M. Serrano and M. Perez-Moreno for the Gt(ROSA)26Sortrn4(ACTB-tdTomato,-EGFP)Luo/J and K15-Cre-PGR mouse lines. We are very grateful to Drs. M. Perez-Moreno, F. Real, O. Uluckan, L. Bakiri and the laboratory members of the Sibilia and Wagner groups for critical reading of the manuscript and valuable suggestions. We thank V. Bermeo, G. Medrano, S. Leceta, O. Grana, and M. Perez for their technical help and IT support. We acknowledge R. Paus laboratory members for the shipment of hair follicle samples. N.G.L. received funding from the People programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 608765. A.I is funded by the Institute of Health Carlos III (PI16/01430). The Wagner laboratory was funded by a grant from the Spanish Ministry of Economy and competitiveness (SAF2015-70857RE, cofounded by the European Regional Development Fund) and is supported by the ERC (ERC-AdG 2016 CSI-Fun).es_ES
dc.publisherWiley es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectepidermal hyper-proliferationes_ES
dc.subjecthair follicle stem cellses_ES
dc.subjectlineage tracinges_ES
dc.subjectthymic stromal lymphopoietines_ES
dc.titleRole of bulge epidermal stem cells and TSLP signaling in psoriasises_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderUnión Europea
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderEuropean Research Council
dc.identifier.journalEMBO molecular medicinees_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Antiguos CNIOes_ES

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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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