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dc.contributor.authorGarcia-Perez, Javier 
dc.contributor.authorLopez-Cima, Maria Felicitas 
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorAragones, Nuria 
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorVidal, Enric 
dc.contributor.authorLopez-Abente, Gonzalo 
dc.date.accessioned2019-03-26T15:35:30Z
dc.date.available2019-03-26T15:35:30Z
dc.date.issued2010-07-15
dc.identifier.citationSci Total Environ. 2010 Jul 15;408(16):3102-12.es_ES
dc.identifier.issn00489697es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7387
dc.description.abstractBACKGROUND: Releases to the environment of pollutants from industrial metal production and processing installations can pose a health problem to humans, owing to the toxic substances that such emissions contain. OBJECTIVES: To investigate whether there might be excess mortality due to tumours of the digestive system among the population residing near Spanish metal production and processing installations included in the European Pollutant Emission Register. METHODS: Ecological study designed to examine mortality due to malignant tumours of the digestive system (oral cavity and pharynx, oesophagus, stomach, pancreas, liver, gallbladder, and colon-rectum) at the municipal level, over the period 1994-2003. Population exposure to pollution was estimated on the basis of distance from town of residence to the pollution source. Using mixed Poisson regression models, we analysed: risk of dying from cancer in a 5-kilometre zone around installations by year of commencement of operations; effect of pollution discharge route (air or water) and type of industrial activity; and risk gradient within a 50-kilometre radius of such installations. RESULTS: Excess mortality (relative risk, 95% confidence interval) was detected in the vicinity of pre-1990 installations for colorectal cancer (1.05, 1.02-1.08 in men; 1.04, 1.00-1.07 in women) and liver cancer (1.06, 1.00-1.12 in men), with this risk being concentrated in installations that released pollution to air. On stratifying by type of industrial activity, statistically significant associations were also observed between the remaining tumours and certain metal production and processing activities. There was also a gradient effect in the proximity to a number of installations. CONCLUSIONS: The results support the existence of an association between risk of dying due to some tumours of the digestive system and residential proximity to the Spanish metal production and processing installations studied.es_ES
dc.description.sponsorshipThis study was funded by a grant from Spain's Health Research Fund (Fondo de Investigación Sanitaria — FIS 040041) and formed part of the MEDEA project (Mortalidad en áreas pequeñas Españolas y Desigualdades socio-Económicas y Ambientales — Mortality in small Spanish areas and socio-economic and environmental inequalities).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshDigestive System Neoplasms es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshChemical Industry es_ES
dc.subject.meshEnvironmental Exposure es_ES
dc.titleMortality due to tumours of the digestive system in towns lying in the vicinity of metal production and processing installationses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID20427078es_ES
dc.format.volume408es_ES
dc.format.number16es_ES
dc.format.page3102-12es_ES
dc.identifier.doi10.1016/j.scitotenv.2010.03.051es_ES
dc.contributor.funderFondo de Investigaciones Sanitarias
dc.identifier.e-issn1879-1026es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.scitotenv.2010.03.051es_ES
dc.identifier.journalThe Science of the total environmentes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional