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dc.contributor.authorCasasnovas, Jose A.
dc.contributor.authorAlcaide, Victor
dc.contributor.authorCiveira, Fernando
dc.contributor.authorGuallar, Eliseo 
dc.contributor.authorIbáñez, Borja 
dc.contributor.authorJimenez-Borreguero, Luis J. 
dc.contributor.authorLaclaustra, Martin 
dc.contributor.authorLeon, Montserrat
dc.contributor.authorPeñalvo, Jose L 
dc.contributor.authorOrdovas, Jose M 
dc.contributor.authorPocovi, Miguel
dc.contributor.authorSanz, Gines 
dc.contributor.authorFuster, Valentin 
dc.date.accessioned2018-10-25T08:19:46Z
dc.date.available2018-10-25T08:19:46Z
dc.date.issued2012
dc.identifierISI:000308809600001
dc.identifier.citationBMC Cardiovasc Disord. 2012; 12(1):45
dc.identifier.issn1471-2261
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6522
dc.description.abstractBackground: Spain, a Mediterranean country with relatively low rates of coronary heart disease, has a high prevalence of traditional cardiovascular risk factors and is experiencing a severe epidemic of overweight/obesity. We designed the Aragon Workers' Health Study (AWHS) to characterize the factors associated with metabolic abnormalities and subclinical atherosclerosis in a middle aged population in Spain free of clinical cardiovascular disease. The objective of this paper is to describe the study design, aims and baseline characteristics of participants in the AWHS. Methods/Design: Longitudinal cohort study based on the annual health exams of 5,400 workers of a car assembly plant in Figueruelas (Zaragoza, Spain). Study participants were recruited during a standardized clinical exam in 2009-2010 (participation rate 95.6\%). Study participants will undergo annual clinical exams and laboratory assays, and baseline and triennial collection of biological materials for biobanking and cardiovascular imaging exams (carotid, femoral and abdominal ultrasonography, coronary calcium score, and ankle-arm blood pressure index). Participants will be followed-up for 10 years. Results: The average (SD) age, body mass index, and waist circumference were 49.3 (8.7) years, 27.7 (3.6) kg/m(2) and 97.2 (9.9) cm, respectively, among males (N = 5,048), and 40.8 (11.6) years, 24.4 (3.8) kg/m(2), and 81.9 (9.9) cm, among females (N = 351). The prevalence of overweight, obesity, current smoking, hypertension, hypercholesterolemia, and diabetes were 55.0, 23.1, 37.1, 40.3, 75.0, and 7.4\%, respectively, among males, and 23.7, 8.3, 45.0, 12.1, 59.5, and 0.6\%, respectively, among females. In the initial 587 study participants who completed all imaging exams (94.5\% male), the prevalence of carotid plaque, femoral plaque, coronary calcium score >1 to 100, and coronary calcium score >100 was 30.3, 56.9, 27.0, and 8.8\%, respectively. 67.7\% of study participants had at least one plaque in the carotid or femoral arteries. Discussion: Baseline data from the AWHS show a high prevalence of cardiovascular risk factors and of sublinical atherosclerosis. Follow-up of this cohort will allow the assessment of subclinical atherosclerosis progression and the link of disease progression to traditional and emergent risk factors.
dc.description.sponsorshipDr. Pocovi was supported in part by grant FIS PS09/0665 from Spain's Fondo de Investigaciones Sanitarias. Dr. Leon was supported in part by grant FIS PS09/01936 from Spain's Fondo de Investigaciones Sanitarias. Dr. Laclaustra was supported in part by grants FIS CP08/00112 and PI10/00021 from Spain's Fondo de Investigaciones Sanitarias.
dc.language.isoeng
dc.publisherBioMed Central (BMC) 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCARDIOVASCULAR RISK-FACTORS
dc.subjectINTIMA-MEDIA THICKNESS
dc.subjectMONICA PROJECT POPULATIONS
dc.subjectSPANISH WORKING POPULATION
dc.subjectCORONARY-HEART-DISEASE
dc.subjectCONSENSUS STATEMENT
dc.subjectAMERICAN SOCIETY
dc.subjectEVENT RATES
dc.subjectTASK-FORCE
dc.subjectPREVALENCE
dc.titleAragon workers' health study - design and cohort description
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID22712826
dc.format.volume12
dc.identifier.doi10.1186/1471-2261-12-45
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2261-12-45
dc.identifier.journalBMC CARDIOVASCULAR DISORDERS
dc.repisalud.orgCNICCNIC::Grupos de investigación::Antiguos CNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales
dc.repisalud.institucionCNIC
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional