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Título
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?
Autor(es)
Toribio-Fernandez, Raquel CNIC | Ceron, Carlos CNIC | Tristão-Pereira, Catarina | Fernandez-Nueda, Irene CNIC | Perez-Castillo, Ana | Fernandez-Ferro, Jose | Moro, Maria Angeles | Ibáñez, Borja CNIC | Fuster, Valentin CNIC | Cortes-Canteli, Marta CNIC
Fecha de publicación
2023-01-12
Cita
Br J Pharmacol . 2023 Jan 12.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated. Both are multifactorial disorders with long asymptomatic phases and similar risk factors. Indeed, CVD signatures such as cerebral microbleeds, micro-infarcts, atherosclerosis, cerebral amyloid angiopathy and a procoagulant state are highly associated with AD. However, AD and CVD co-development and the molecular mechanisms underlying such associations are not understood. Here, we review the evidence regarding the vascular component of AD and clinical studies using anticoagulants that specifically evaluated the development of AD and other dementias. Most studies reported a markedly decreased incidence of composite dementia in anticoagulated patients with atrial fibrillation, with the highest benefit for direct oral anticoagulants. However, sub-analyses by differential dementia diagnosis were scarce and inconclusive. We finally discuss whether anticoagulation could be a plausible preventive/therapeutic approach for AD and, if so, which would be the best drug and strategy to maximize clinical benefit and minimize potential risks.
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- Oral anticoagulants_Br J Pharm ...
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