Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16709
Título
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis.
Autor(es)
Devesa, Ana | Fuster, Valentin CNIC | Vazirani, Ravi | Garcia-Lunar, Ines CNIC | Oliva, Belen CNIC | Espana, Samuel CNIC | Moreno-Arciniegas, Andrea | Sanz, Javier CNIC | Perez-Herreras, Cristina | Bueno, Hector CNIC | Lara-Pezzi, Enrique CNIC | Garcia-Alvarez, Ana CNIC | de Vega, Vicente Martínez | Fernandez-Friera, Leticia CNIC | Trivieri, Maria G | Fernandez-Ortiz, Antonio CNIC | Rossello, Xavier CNIC | Sanchez-Gonzalez, Javier CNIC | Ibáñez, Borja CNIC
Fecha de publicación
2023-11-01
Cita
Diabetes Care. 2023 Nov 1;46(11):2050-2057.
Idioma
Inglés
Tipo de documento
journal article
Resumen
OBJECTIVE
Experimental evidence suggests that metabolic syndrome (MetS) is associated with changes in cardiac metabolism. Whether this association occurs in humans is unknown.
RESEARCH DESIGN AND METHODS
821 asymptomatic individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study (50.6 [46.9-53.6] years, 83.7% male) underwent two whole-body 18F-fluorodeoxyglucose positron emission tomography-magnetic resonance (18F-FDG PET-MR) 4.8 ± 0.6 years apart. Presence of myocardial 18F-FDG uptake was evaluated qualitatively and quantitatively. No myocardial uptake was grade 0, while positive uptake was classified in grades 1-3 according to target-to-background ratio tertiles.
RESULTS
One hundred fifty-six participants (19.0%) showed no myocardial 18F-FDG uptake, and this was significantly associated with higher prevalence of MetS (29.0% vs. 13.9%, P < 0.001), hypertension (29.0% vs. 18.0%, P = 0.002), and diabetes (11.0% vs. 3.2%, P < 0.001), and with higher insulin resistance index (HOMA-IR, 1.64% vs. 1.23%, P < 0.001). Absence of myocardial uptake was associated with higher prevalence of early atherosclerosis (i.e., arterial 18F-FDG uptake, P = 0.004). On follow-up, the associations between myocardial 18F-FDG uptake and risk factors were replicated, and MetS was more frequent in the group without myocardial uptake. The increase in HOMA-IR was associated with a progressive decrease in myocardial uptake (P < 0.001). In 82% of subjects, the categorization according to presence/absence of myocardial 18F-FDG uptake did not change between baseline and follow-up. MetS regression on follow-up was associated with a significant (P < 0.001) increase in myocardial uptake.
CONCLUSIONS
Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.
MESH
Metabolic Syndrome | Insulin Resistance | Atherosclerosis | Male | Humans | Female | Fluorodeoxyglucose F18 | Heart | Positron-Emission Tomography | Radiopharmaceuticals
Versión en línea
DOI
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