Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16637
Título
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.
Autor(es)
Kumar, Rahul | Aktay-Cetin, Öznur | Craddock, Vaughn | Morales-Cano, Daniel | Kosanovic, Djuro | Cogolludo, Angel | Perez-Vizcaino, Francisco | Avdeev, Sergey | Kumar, Ashok | Ram, Anil Kumar | Agarwal, Stuti | Chakraborty, Ananya | Savai, Rajkumar | de Jesus Perez, Vinicio | Graham, Brian B | Butrous, Ghazwan | Dhillon, Navneet K
Fecha de publicación
2023-01
Cita
PLoS Pathog. 2023 Jan 12;19(1):e1011063.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.
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