Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16451
Título
Long-term prognostic impact of beta-blockers in patients with Takotsubo syndrome: Results from the RETAKO Registry.
Autor(es)
Raposeiras-Roubín, Sergio | Núñez-Gil, Iván J | Jamhour, Karim | Abu-Assi, Emad | Conty, David Aritza | Vedia, Oscar | Almendro-Delia, Manuel | Sionis, Alessandro | Martin-Garcia, Agustin C | Corbí-Pascual, Miguel | Martínez-Sellés, Manuel | Uribarri, Aitor | Guillén, Marta | Acuña, José María García | País, Javier Lopez | Blanco, Emilia | Linares Vicente, José A | Flecha, Alejandro Sánchez Grande | Andrés, Mireia | Pérez-Castellanos, Alberto | Alonso, Joaquín | Rosselló, Xavier | Romo, Andrés Iñiguez | Feltes, Gisela
Fecha de publicación
2023-03
Cita
Rev Port Cardiol. 2023 Mar;42(3):237-246.
Idioma
Inglés
Tipo de documento
journal article
Resumen
BACKGROUND
No evidence-based therapy has yet been established for Takotsubo syndrome (TTS). Given the putative harmful effects of catecholamines in patients with TTS, beta-blockers may potentially decrease the intensity of the detrimental cardiac effects in those patients.
OBJECTIVE
The purpose of this study was to assess the impact of beta-blocker therapy on long-term mortality and TTS recurrence.
METHODS
The cohort study used the national Spanish Registry on TakoTsubo Syndrome (RETAKO). A total of 970 TTS post-discharge survivors, without pheochromocytoma, left ventricular outflow tract obstruction, sustained ventricular arrhythmias, and significant bradyarrhythmias, between January 1, 2003, and July 31, 2018, were assessed. Cox regression analysis and inverse probability weighting (IPW) propensity score analysis were used to evaluate the association between beta-blocker therapy and survival free of TTS recurrence.
RESULTS
From 970 TTS patients, 582 (60.0%) received beta-blockers. During a mean follow-up of 2.5±3.3 years, there were 87 deaths (3.6 per 100 patients/year) and 29 TTS recurrences (1.2 per 100 patient/year). There was no significant difference in follow-up mortality or TTS recurrence in unadjusted and adjusted Cox analysis (hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.59-1.27, and 0.95, 95% CI 0.57-1.13, respectively). After weighting and adjusting by IPW, differences in one-year survival free of TTS recurrence between patients treated and untreated with beta-blockers were not found (average treatment effect -0.01, 95% CI -0.07 to 0.04; p=0.621).
CONCLUSIONS
In this observational nationwide study from Spain, there was no significant association between beta-blocker therapy and follow-up survival free of TTS recurrence.
MESH
Takotsubo Cardiomyopathy | Humans | Aftercare | Cohort Studies | Patient Discharge | Prognosis | Registries
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- Long_term prognostic_Rev Port ...
- Tamaño:
- 1.672Mb
- Formato:
- Descripción:
- Artículo