Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15684
Título
Title: p38δ Regulates IL6 Expression Modulating ERK Phosphorylation in Preadipocytes.
Autor(es)
Fecha de publicación
2021
Cita
Front Cell Dev Biol. 2022 Jan 17;9:708844
Idioma
Inglés
Tipo de documento
journal article
Resumen
IL6 is an essential cytokine in metabolism regulation and for intercommunication among different organs and tissues. IL6 produced by different tissues has different functions and therefore it is very important to understand the mechanism of its expression in adipose tissue. In this work we demonstrated that IL6 expression in mouse preadipocytes, like in human, is partially dependent on Wnt5a and JNK. Using mouse preadipocytes lacking each one of the p38 SAPK family members, we have shown that IL6 expression is also p38γ and p38δ dependent. In fact, the lack of some of these two kinases increases IL6 expression without altering that of Wnt5a. Moreover, we show that the absence of p38δ promotes greater ERK1/2 phosphorylation in a MEK1/2 independent manner, and that this increased ERK1/2 phosphorylation state is contributing to the higher IL6 expression in p38δ-/- preadipocytes. These results suggest a new crosstalk between two MAPK signaling pathway, p38δ and ERK1/2, where p38δ modulates the phosphorylation state of ERK1/2.
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
- Nombre:
- Title p38δ Regulates IL6 Expression ...
- Tamaño:
- 2.110Mb
- Formato:
- Descripción:
- Artículo