Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15670
Título
Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses.
Autor(es)
Dosil, Sara G | Lopez-Cobo, Sheila | Rodriguez-Galan, Ana CNIC | Fernandez-Delgado, Irene CNIC | Ramirez-Huesca, Marta CNIC | Milan-Rois, Paula | Castellanos, Milagros | Somoza, Alvaro | Gómez, Manuel José | Reyburn, Hugh T | Vales-Gomez, Mar | Sánchez Madrid, Francisco | Fernandez-Messina, Lola CNIC
Fecha de publicación
2022-07-29
Cita
Elife. 2022 Jul 29;11:e76319
Idioma
Inglés
Tipo de documento
journal article
Resumen
Natural killer (NK) cells recognize and kill target cells undergoing different types of stress. NK cells are also capable of modulating immune responses. In particular, they regulate T cell functions. Small RNA next-generation sequencing of resting and activated human NK cells and their secreted extracellular vesicles (EVs) led to the identification of a specific repertoire of NK-EV-associated microRNAs and their post-transcriptional modifications signature. Several microRNAs of NK-EVs, namely miR-10b-5p, miR-92a-3p, and miR-155-5p, specifically target molecules involved in Th1 responses. NK-EVs promote the downregulation of GATA3 mRNA in CD4+ T cells and subsequent TBX21 de-repression that leads to Th1 polarization and IFN-γ and IL-2 production. NK-EVs also have an effect on monocyte and moDCs (monocyte-derived dendritic cells) function, driving their activation and increased presentation and costimulatory functions. Nanoparticle-delivered NK-EV microRNAs partially recapitulate NK-EV effects in mice. Our results provide new insights on the immunomodulatory roles of NK-EVs that may help to improve their use as immunotherapeutic tools.
MESH
Extracellular Vesicles | MicroRNAs | Animals | Humans | Killer Cells, Natural | Mice | RNA, Messenger | T-Lymphocytes
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