Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15648
Título
Pluripotency factors regulate the onset of Hox cluster activation in the early embryo.
Autor(es)
Tiana, María | Lopez-Jimenez, Elena CNIC | Sainz de Aja, Julio CNIC | Barral, Antonio CNIC | Victorino, Jesus | Badia-Careaga, Claudio CNIC | Rollan, Isabel CNIC | Rouco, Raquel CNIC | Santos, Elisa | Sanchez-Iranzo, Hector | Acemel, Rafael D | Torroja, Carlos CNIC | Adan, Javier CNIC | Andrés-León, Eduardo | Gomez-Skarmeta, Jose Luis | Giovinazzo, Giovanna CNIC | Sanchez-Cabo, Fatima CNIC | Manzanares, Miguel CNIC
Fecha de publicación
2022-07-15
Cita
Sci Adv. 2022 Jul 15;8(28):eabo3583
Idioma
Inglés
Tipo de documento
journal article
Resumen
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during early phases of differentiation, and their role in the transition from pluripotency to lineage specification is largely unknown. We found that pluripotency factors play a dual role in regulating key lineage specifiers, initially repressing their expression and later being required for their proper activation. We show that Oct4 is necessary for activation of HoxB genes during differentiation of embryonic stem cells and in the embryo. In addition, we show that the HoxB cluster is coordinately regulated by OCT4 binding sites located at the 3' end of the cluster. Our results show that core pluripotency factors are not limited to maintaining the precommitted epiblast but are also necessary for the proper deployment of subsequent developmental programs.
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- Pluripotency factors regulate ...
- Tamaño:
- 948.4Kb
- Formato:
- Descripción:
- Artículo