Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15645
Título
The central clock suffices to drive the majority of circulatory metabolic rhythms.
Autor(es)
Petrus, Paul | Smith, Jacob G | Koronowski, Kevin B | Chen, Siwei | Sato, Tomoki | Greco, Carolina M | Mortimer, Thomas | Welz, Patrick-Simon | Zinna, Valentina M | Shimaji, Kohei | Cervantes, Marlene | Punzo, Daniela | Baldi, Pierre | Muñoz-Cánoves, Pura | Sassone-Corsi, Paolo | Benitah, Salvador Aznar
Fecha de publicación
2022-07
Cita
Sci Adv. 2022 Jul;8(26):eabo2896
Idioma
Inglés
Tipo de documento
journal article
Resumen
Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue communication is mediated, in part, by temporal coordination of metabolism. Here, we characterize the extent to which clocks in different organs control systemic metabolic rhythms, an area that remains largely unexplored. We analyzed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1. Having functional hepatic and muscle clocks can only drive a minority (13%) of systemic metabolic rhythms. Conversely, limiting Bmal1 expression to the central pacemaker in the brain restores rhythms to 57% of circulatory metabolites. Rhythmic feeding imposed on clockless mice resulted in a similar rescue, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals.
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- The central clock suffices Sci ...
- Tamaño:
- 2.509Mb
- Formato:
- Descripción:
- Artículo