Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15634
Título
Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP.
Autor(es)
Garcia-Garcia, Maria CNIC | Sánchez-Perales, Sara | Jarabo, Patricia | Calvo, Enrique CNIC | Huyton, Trevor | Fu, Liran | Ng, Sheung Chun | Sotodosos-Alonso, Laura | Vazquez, Jesus CNIC | Casas-Tintó, Sergio | Görlich, Dirk | Echarri, Asier CNIC | del Pozo, Miguel Angel CNIC
Fecha de publicación
2022-03-04
Cita
Nat Commun. 2022 Mar 4;13(1):1174
Idioma
Inglés
Tipo de documento
journal article
Resumen
Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an essential step for mechanotransduction. However, how mechanical forces regulate the nuclear import process is not understood. Here, we identify a highly mechanoresponsive nuclear transport receptor (NTR), Importin-7 (Imp7), that drives the nuclear import of YAP, a key regulator of mechanotransduction pathways. Unexpectedly, YAP governs the mechanoresponse of Imp7 by forming a YAP/Imp7 complex that responds to mechanical cues through the Hippo kinases MST1/2. Furthermore, YAP behaves as a dominant cargo of Imp7, restricting the Imp7 binding and the nuclear translocation of other Imp7 cargoes such as Smad3 and Erk2. Thus, the nuclear import process is an additional regulatory layer indirectly regulated by mechanical cues, which activate a preferential Imp7 cargo, YAP, which competes out other cargoes, resulting in signaling crosstalk.
MESH
Cell Nucleus | Mechanotransduction, Cellular | Active Transport, Cell Nucleus | Karyopherins | Receptors, Cytoplasmic and Nuclear
Versión en línea
DOI
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