Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15264
Título
Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm.
Autor(es)
Roldán-Montero, Raquel | Pérez-Sáez, Juan M | Cerro-Pardo, Isabel | Oller, Jorge CNIC | Martinez-Lopez, Diego | Nunez, Estefania CNIC | Maller, Sebastian M | Gutierrez-Muñoz, Carmen | Mendez-Barbero, Nerea CNIC | Escola-Gil, Joan C | Michel, Jean-Baptiste | Mittelbrunn, Maria | Vazquez, Jesus CNIC | Blanco-Colio, Luis M | Rabinovich, Gabriel A | Martin-Ventura, Jose L
Fecha de publicación
2022-03-18
Cita
Sci Adv. 2022 Mar 18;8(11):eabm7322
Idioma
Inglés
Tipo de documento
journal article
Resumen
Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside-binding protein, as a therapeutic target for atherosclerosis and AAA. Mice lacking Gal-1 (Lgals1-/-) developed severe atherosclerosis induced by pAAV/D377Y-mPCSK9 adenovirus and displayed higher lipid levels and lower expression of contractile markers of vascular smooth muscle cells (VSMCs) in plaques than wild-type mice. Proteomic analysis of Lgals1-/- aortas showed changes in markers of VSMC phenotypic switch and altered composition of mitochondrial proteins. Mechanistically, Gal-1 silencing resulted in increased foam cell formation and mitochondrial dysfunction in VSMCs, while treatment with recombinant Gal-1 (rGal-1) prevented these effects. Furthermore, rGal-1 treatment attenuated atherosclerosis and elastase-induced AAA, leading to higher contractile VSMCs in aortic tissues. Gal-1 expression decreased in human atheroma and AAA compared to control tissue. Thus, Gal-1-driven circuits emerge as potential therapeutic strategies in atherosclerosis and AAA.
MESH
Aortic Aneurysm, Abdominal | Atherosclerosis | Animals | Disease Models, Animal | Galectin 1 | Mice | Mice, Inbred C57BL | Muscle, Smooth, Vascular | Proteomics | Vascular Remodeling
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