Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15256
Título
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses.
Autor(es)
Fecha de publicación
2022-10-11
Cita
Cell Rep. 2022 Oct 11;41(2):111468
Idioma
Inglés
Tipo de documento
journal article
Resumen
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1fl/flAicda-Cre+/kiLdlr-/- pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis.
MESH
Atherosclerosis | Vaccines | Animals | Antibody Formation | Germinal Center | Lipoproteins, LDL | Malondialdehyde | Mice | Vaccination
Versión en línea
DOI
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- Nombre:
- MDA_LDL vaccination induces Cell ...
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