Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15172
Título
Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis.
Autor(es)
Crespo, María | Nikolic, Ivana CNIC | Mora, Alfonso CNIC | Rodríguez, Elena | Leiva-Vega, Luis CNIC | Pintor-Chocano, Aránzazu | Horrillo, Daniel | Hernández-Cosido, Lourdes | Torres, Jorge L | Novoa, Eva | Nogueiras, Rubén | Medina-Gómez, Gema | Marcos, Miguel | Leiva, Magdalena CNIC | Sabio, Guadalupe CNIC
Fecha de publicación
2022-05-19
Cita
Hepatology. 2022 May 19. doi: 10.1002/hep.32581.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low-grade inflammation that contributes to the development of diabetes, steatosis, and insulin resistance. Recent research has shown that this chronic inflammation is crucially dependent on p38 pathway activity in macrophages, suggesting p38 inhibition as a possible treatment for obesity comorbidities. Nevertheless, we report here that lack of p38 activation in myeloid cells worsens high-fat diet-induced obesity, diabetes, and steatosis. Deficient p38 activation increases macrophage IL-12 production, leading to inhibition of hepatic FGF21 and reduction of thermogenesis in the brown fat. The implication of FGF21 in the phenotype was confirmed by its specific deletion in hepatocytes. We also found that IL-12 correlates with liver damage in human biopsies, indicating the translational potential of our results. Our findings suggest that myeloid p38 has a dual role in inflammation and that drugs targeting IL-12 might improve the homeostatic regulation of energy balance in response to metabolic stress.
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