Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15107
Título
CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
Autor(es)
Blanco-Domínguez, Rafael | de la Fuente, Hortensia CNIC | Rodríguez, Cristina | Martín-Aguado, Laura | Sánchez-Díaz, Raquel | Jiménez-Alejandre, Rosa | Rodriguez-Arabaolaza, Iker CNIC | Curtabbi, Andrea | Garcia-Guimaraes, Marcos M | Vera, Alberto | Rivero, Fernando | Cuesta, Javier | Jimenez-Borreguero, Luis Jesus | Cecconi, Alberto | Duran-Cambra, Albert | Taurón, Manel | Alonso, Judith | Bueno, Hector CNIC | Villalba-Orero, María | Enriquez, Jose Antonio CNIC | Robson, Simon C | Alfonso, Fernando | Sánchez-Madrid, Francisco | Martínez-González, José | Martin, Pilar CNIC | Garcia-Guimaraes, Marcos M. | Robson, Simon C.
Fecha de publicación
2022-09-06
Cita
J Clin Invest . 2022 Sep 6;e152418.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Increasing evidences advocate for an important function of T cells in controlling immune homeostasis and pathogenesis after myocardial infarction (MI), although the underlying molecular mechanisms remain elusive. In this study, a broad analysis of immune markers in 283 patients revealed a significant CD69 overexpression on Treg cells after MI. Our results in mice showed that CD69 expression on Treg cells increased survival after left-anterior-descending coronary artery (LAD)-ligation. Cd69-/- mice developed strong IL-17+ γδT cell responses after ischemia that increased myocardial inflammation and, consequently, worsened cardiac function. CD69+ Treg cells, by induction of AhR-dependent CD39 ectonucleotidase activity, induced apoptosis and decreased IL-17A production in γδT cells. Adoptive transfer of CD69+ Treg cells to Cd69-/- mice after LAD-ligation reduced IL-17+ γδT cell recruitment, thus increasing survival. Consistently, clinical data from two independent cohorts of patients indicated that increased CD69 expression in peripheral blood cells after acute MI was associated with a lower risk of re-hospitalization for heart failure (HF) after 2.5 years of follow-up. This result remained significant after adjustment for age, sex and traditional cardiac damage biomarkers. Our data highlight CD69 expression on Treg cells as a potential prognostic factor and a therapeutic option to prevent HF after MI.
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