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Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.

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dc.contributor.authorPérez-Belmonte, Luis M
dc.contributor.authorMoreno-Santos, Inmaculada
dc.contributor.authorCabrera-Bueno, Fernando
dc.contributor.authorSánchez-Espín, Gemma
dc.contributor.authorCastellano, Daniel
dc.contributor.authorSuch, Miguel
dc.contributor.authorCrespo-Leiro, María G
dc.contributor.authorCarrasco-Chinchilla, Fernando
dc.contributor.authorAlonso-Pulpón, Luis
dc.contributor.authorLópez-Garrido, Miguel
dc.contributor.authorRuiz-Salas, Amalio
dc.contributor.authorBecerra-Muñoz, Víctor M
dc.contributor.authorGómez-Doblas, Juan J
dc.contributor.authorde Teresa-Galván, Eduardo
dc.contributor.authorJiménez-Navarro, Manuel
dc.date.accessioned2024-01-23T20:12:30Z
dc.date.available2024-01-23T20:12:30Z
dc.date.issued2017-02-23
dc.description.abstractObjectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p
dc.format.number3es_ES
dc.format.page268-274es_ES
dc.format.volume14es_ES
dc.identifier.doi10.7150/ijms.17821
dc.identifier.e-issn1449-1907es_ES
dc.identifier.journalInternational journal of medical scienceses_ES
dc.identifier.otherhttp://hdl.handle.net/10668/11037
dc.identifier.pubmedID28367087es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17292
dc.language.isoeng
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectSterol regulatory element-binding proteins (SREBP)
dc.subjectcoronary artery disease
dc.subjectepicardial adipose tissue
dc.subjecttype-2 diabetes mellitus.
dc.subject.meshAdipose Tissue
dc.subject.meshAged
dc.subject.meshCoronary Artery Disease
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLipid Metabolism
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPericardium
dc.subject.meshRisk Factors
dc.subject.meshSterol Regulatory Element Binding Protein 1
dc.subject.meshSterol Regulatory Element Binding Protein 2
dc.subject.meshSterols
dc.titleExpression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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