Publication:
Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization.

Simple item page
dc.contributor.authorGarcía-Poyatos, Carolina
dc.contributor.authorArora, Prateek
dc.contributor.authorCalvo, Enrique
dc.contributor.authorMarques, Ines J
dc.contributor.authorKirschke, Nick
dc.contributor.authorGalardi-Castilla, Maria
dc.contributor.authorLembke, Carla
dc.contributor.authorMeer, Marco
dc.contributor.authorFernández-Montes, Paula
dc.contributor.authorErnst, Alexander
dc.contributor.authorHaberthür, David
dc.contributor.authorHlushchuk, Ruslan
dc.contributor.authorVázquez, Jesús
dc.contributor.authorVermathen, Peter
dc.contributor.authorEnríquez, José Antonio
dc.contributor.authorMercader, Nadia
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)
dc.contributor.funderUnión Europea. Comisión Europea. H2020
dc.contributor.funderUnión Europea. Comisión Europea. NextGenerationEU
dc.contributor.funderPlan de Recuperación, Transformación y Resiliencia (España)
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERFES (Fragilidad y Envejecimiento Saludable)
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderFondation Leducq
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderComunidad de Madrid (España)
dc.contributor.funderFundación La Caixa
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
dc.date.accessioned2024-12-04T10:42:20Z
dc.date.available2024-12-04T10:42:20Z
dc.date.issued2024-07-22
dc.descriptionWe thank Anna Gliwa, Ahmet Kurk, Xavier Langa, and Eduardo Diaz for fish husbandry at the University of Bern and CNIC; Beat Hanni for TEM tissue preparation; and Indre Piragyte for experimental support. Microscopes supported by the Microscopy Imaging Center (MIC) at the University of Bern were used. Transcriptomics and Proteomics were performed at the Genomics Unit and Proteomics Unit of CNIC, respectively. N.M. was funded by SNF grant 320030E-164245, an ERC consolidator grant 2018 819717, H2020-SC1- 2019-Single-Stage-RTD REANIMA-874764, and HSFP RGP0016/2018. P.V. has been funded by SNF grant 310030_192691. J.A.E. is supported by RTI2018-099357-B-I00, PID2021-1279880B, and TED2021-131611B-I00 funded by MCIN/AEI/10.13039/501100011033 and the European Union ‘‘NextGenerationEU’’/Plan de Recuperación Transformación y Resiliencia, PRTR, HSFP RGP0016/2018, CIBERFES (CB16/10/00282), and 17CVD04 Foundation Leducq. J.V. was funded by the Spanish Ministry of Science, Innovation and Universities (PGC2018-097019-B-I00, PID2021-122348NB-I00, PLEC2022-009235, and PLEC2022-009298), the Instituto de Salud Carlos III (Fondo de Investigacio´ n Sanitaria grant PRB3) (PT17/0019/0003-ISCIIISGEFI/ERDF, ProteoRed), Comunidad de Madrid (IMMUNO-VAR, P2022/BMD-7333), and ‘‘la Caixa’’ Banking Foundation (project codes HR17-00247 and HR22-00253). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Spanish Ministry of Science, Innovation and Universities, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033).
dc.description.abstractThe oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1 hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1 and cox7a2l underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.
dc.description.peerreviewedSí
dc.format.number14
dc.format.page1824-1841
dc.format.volume59
dc.identifier.citationDev Cell. 2024 Jul 22;59(14):1824-1841.e10.
dc.identifier.journalDevelopmental Cell
dc.identifier.pubmedID38701784
dc.identifier.urihttps://hdl.handle.net/20.500.12105/25850
dc.language.isoeng
dc.publisherCell Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ERC/CoG/819717
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/H2020-SC1-2019-Single-Stage-RTD/REANIMA-874764
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-099357-B-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2021-1279880B
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/TED2021-131611B-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RGP0016/2018
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CB16/10/00282
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PGC2018-097019-B-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2021-122348NB-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PLEC2022-009235
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PLEC2022-009298
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PT17/0019/0003-ISCIIISGEFI/ERDF/ProteoRed
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/P2022/IMMUNO-VAR/BMD-7333
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/HR17-00247
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/HR22-00253
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MICIN/AEI/10.13039/501100011033/CEX2020-001041-S
dc.relation.publisherversionhttps://10.1016/j.devcel.2024.04.012
dc.repisalud.institucionCNIC
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa
dc.rights.accessRightsopen access
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCa(2+) signaling
dc.subjectcox7a1
dc.subjectcox7a2l
dc.subjectelectron transport chain
dc.subjectheart regeneration
dc.subjectmetabolic rewiring
dc.subjectmitochondria
dc.subjectmuscle physiology
dc.subjectscaf1
dc.subjectsupercomplex assembly
dc.subjectzebrafish
dc.titleCox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization.
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cox7a1 controls skeletal muscle_Dev Cell_2024.pdf
Size:
7.79 MB
Format:
Adobe Portable Document Format
Download

Collections

Grupos de investigación