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Current Understanding of the Neural Stem Cell Niches.

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dc.contributor.authorLlorente, Vicente
dc.contributor.authorVelarde, Pedro
dc.contributor.authorDesco, Manuel
dc.contributor.authorGómez-Gaviro, María Victoria
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)es_ES
dc.contributor.funderComunidad de Madrid (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)es_ES
dc.date.accessioned2023-03-23T10:48:06Z
dc.date.available2023-03-23T10:48:06Z
dc.date.issued2022-09-26
dc.description.abstractNeural stem cells (NSCs) are self-renewing, multipotent cells which give rise to all components of the central nervous system (CNS) during embryogenesis, but also activate in response to injury and disease and maintain a certain level of neurogenic activity throughout adulthood. This activity takes place in specialized regions of the brain, the neurovascular niches, whose main role is to control the behaviour of the CNS. In adult mammals, two main "canonical" niches have been described: The subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus. This review discusses our current understanding of the neural stem cells and their canonical niches, as well as their structure, behaviours, and role in neural disease.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis research was funded by the Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III grants PI18/00462 to M.V.G.-G. and PT20/00044 to M.D., was cofinanced by the European Regional Development Fund, “A way of making Europe” initiative. This work was partially supported by Comunidad de Madrid (S2017/BMD-3867 RENIM-CM) and cofinanced by the European Structural and Investment Fund. This study was also supported by the Plan Estatal de I+D+I 2013–2016, with funding from the European Regional Development Fund (ERDF), “A way to build Europe” initiative. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation and is a Severo Ochoa Centre of Excellence (SEV-2015-0505).es_ES
dc.format.number19es_ES
dc.format.volume11es_ES
dc.identifier.citationCells. 2022 Sep 26;11(19):3002es_ES
dc.identifier.doi10.3390/cells11193002es_ES
dc.identifier.e-issn2073-4409es_ES
dc.identifier.journalCellses_ES
dc.identifier.pubmedID36230964es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15698
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PI18/00462es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/S2017/BMD-3867es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.publisherversion10.3390/cells11193002es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshNeural Stem Cellses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshLateral Ventricleses_ES
dc.subject.meshMammalses_ES
dc.subject.meshMultipotent Stem Cellses_ES
dc.subject.meshNeurogenesises_ES
dc.subject.meshStem Cell Nichees_ES
dc.titleCurrent Understanding of the Neural Stem Cell Niches.es_ES
dc.typereviewes_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication3d8c68c5-1cf7-41e7-bc20-a44a703ae994
relation.isAuthorOfPublication.latestForDiscovery3d8c68c5-1cf7-41e7-bc20-a44a703ae994

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