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Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus.

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dc.contributor.authorLetrado, Patricia
dc.contributor.authorCorsini, Bruno
dc.contributor.authorDíez-Martínez, Roberto
dc.contributor.authorBustamante, Noemí
dc.contributor.authorYuste, Jose Enrique
dc.contributor.authorGarcía, Pedro
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.date.accessioned2020-11-17T13:24:56Z
dc.date.available2020-11-17T13:24:56Z
dc.date.issued2018
dc.description.abstractTo test the synergistic effect of Cpl-711 endolysin and antibiotics for antipneumococcal activity. A combination of Cpl-711 and different antibiotics (amoxicillin, cefotaxime, levofloxacin and vancomycin) was tested in a checkerboard assay against several multidrug-resistant Streptococcus pneumoniae strains. Mouse and zebrafish models of pneumococcal sepsis were used to confirm the in vitro data. The activity of Cpl-711 combined with amoxicillin or cefotaxime was synergistic in the bactericidal effect against a serotype 23F multiresistant clinical isolate of S. pneumoniae. Synergy between Cpl-711 and cefotaxime was validated using both mouse and zebrafish models. Combination of Cpl-711 and cefotaxime may help in the treatment of diseases caused by multiresistant pneumococcal strains.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis research was supported by grants from the Ministerio de Economía y Competitividad (MINECO) to P García (SAF2017-88664) and JE Yuste (SAF2017-83388). Additional funding was provided by the CIBER de Enfermedades Respiratorias (CIBERES), an initiative of the Instituto de Salud Carlos III (ISCIII). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.es_ES
dc.format.page1215-1223es_ES
dc.format.volume13es_ES
dc.identifier.citationFuture Microbiol . 2018 Sep;13(11):1215-1223.es_ES
dc.identifier.doi10.2217/fmb-2018-0077es_ES
dc.identifier.e-issn1746-0921
dc.identifier.journalFuture microbiologyes_ES
dc.identifier.pubmedID30238774es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11357
dc.language.isoenges_ES
dc.publisherFuture Medicinees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-88664es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-83388es_ES
dc.relation.publisherversionhttps://doi.org/10.2217/fmb-2018-0077es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectStreptococcus pneumoniaees_ES
dc.subjectantibiotic multidrug-resistantes_ES
dc.subjectendolysines_ES
dc.subjectmouse modeles_ES
dc.subjectsynergyes_ES
dc.subjectzebrafish modeles_ES
dc.subject.meshDrug Resistance, Multiple, Bacteriales_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Bacterial Agentses_ES
dc.subject.meshCefotaximees_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDrug Synergismes_ES
dc.subject.meshFemalees_ES
dc.subject.meshMicees_ES
dc.subject.meshMice, Inbred BALB Ces_ES
dc.subject.meshMuramidasees_ES
dc.subject.meshPneumococcal Infectionses_ES
dc.subject.meshRecombinant Fusion Proteinses_ES
dc.subject.meshSepsises_ES
dc.subject.meshStreptococcus Phageses_ES
dc.subject.meshStreptococcus pneumoniaees_ES
dc.subject.meshZebrafishes_ES
dc.titleBactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationa4571e1b-7c96-4595-9210-be1c45ed7435
relation.isAuthorOfPublication8e36a2c1-2c2c-4d30-90ad-e0d92630c74f
relation.isAuthorOfPublication.latestForDiscoverya4571e1b-7c96-4595-9210-be1c45ed7435

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