Publication:
Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study

Simple item page
dc.contributor.authorPerez-Garcia, Felipe
dc.contributor.authorVázquez-Morón, Sonia
dc.contributor.authorBurgueño-García, Iván
dc.contributor.authorMuñoz-Gómez, María José
dc.contributor.authorZea-Sevilla, María Ascensión
dc.contributor.authorCalero, Miguel
dc.contributor.authorMartinez, Isidoro
dc.contributor.authorRábano, Alberto
dc.contributor.authorResino, Salvador
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.date.accessioned2024-01-24T14:10:00Z
dc.date.available2024-01-24T14:10:00Z
dc.date.issued2023-04-12
dc.description.abstractIn this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by awards from the Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (grant CB21/13/00044 to S. R.) and Agencia Estatal de Investigación (grant PID2019-110401RB-100 to M. C.).es_ES
dc.format.number7es_ES
dc.format.page873-877es_ES
dc.format.volume227es_ES
dc.identifier.citationJ Infect Dis. 2023 Apr 12;227(7):873-877.es_ES
dc.identifier.doi10.1093/infdis/jiac268es_ES
dc.identifier.e-issn1537-6613es_ES
dc.identifier.journalThe Journal of infectious diseaseses_ES
dc.identifier.pubmedID35759220es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17363
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PID2019-110401RB-100es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CB21/13/00044es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/infdis/jiac268es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlzheimeres_ES
dc.subjectHepatitis E viruses_ES
dc.subjectNeurodegenerative disorderses_ES
dc.subjectOlder peoplees_ES
dc.subjectSeroprevalencees_ES
dc.subjectVascular pathologyes_ES
dc.subject.meshHepatitis E viruses_ES
dc.subject.meshHepatitis Ees_ES
dc.subject.meshNeurodegenerative Diseaseses_ES
dc.subject.meshDementiaes_ES
dc.subject.meshHumanses_ES
dc.subject.meshAgedes_ES
dc.subject.meshSeroepidemiologic Studieses_ES
dc.subject.meshCase-Control Studieses_ES
dc.subject.meshHepatitis Antibodieses_ES
dc.subject.meshImmunoglobulin Mes_ES
dc.titleHepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Studyes_ES
dc.typeresearch articlees_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication2d150dc2-661b-4d69-897f-6b8a80b31861
relation.isAuthorOfPublication67f2bc43-2edd-4446-a434-c8145a43f451
relation.isAuthorOfPublication0a5ce675-0dc5-483a-b8be-b573f3757285
relation.isAuthorOfPublication7b0177ec-7b89-4d97-813b-14c5ae64fc28
relation.isAuthorOfPublication91fafbb0-4d25-4be8-969e-5b9941af71ca
relation.isAuthorOfPublication89b17350-14e3-4dfd-b797-6ee6ca5363b8
relation.isAuthorOfPublication.latestForDiscovery2d150dc2-661b-4d69-897f-6b8a80b31861
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hepatitis_E_VirusSeroprevalence_2023.pdf
Size:
1.79 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Centro Nacional de Microbiología (CNM)
Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)