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Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers

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dc.contributor.authorMartínez-Sanz, Javier
dc.contributor.authorJiménez, Daniel
dc.contributor.authorMartínez-Campelo, Laura
dc.contributor.authorCruz, Raquel
dc.contributor.authorVizcarra, Pilar
dc.contributor.authorSánchez-Conde, Matilde
dc.contributor.authorRon, Raquel
dc.contributor.authorRodríguez, Mario
dc.contributor.authorHerrera, Sabina
dc.contributor.authorMoreno, Santiago
dc.contributor.authorLopez-Huertas, Maria Rosa
dc.contributor.authorSerrano-Villar, Sergio
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMerck, Sharp & Dohme
dc.date.accessioned2022-03-25T12:56:44Z
dc.date.available2022-03-25T12:56:44Z
dc.date.issued2021-12
dc.description.abstractWe aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by Instituto de Salud Carlos III: [grant number AC17/00019,COV20/00349,PI18/00154,PT17/0019]; Merck, Sharp & Dohme: [Ref IISP 59181].es_ES
dc.format.number1es_ES
dc.format.page493-496es_ES
dc.format.volume10es_ES
dc.identifier.citationEmerg Microbes Infect. 2021 Dec;10(1):493-496.es_ES
dc.identifier.doi10.1080/22221751.2021.1902755es_ES
dc.identifier.e-issn2222-1751es_ES
dc.identifier.journalEmerging Microbes & Infectionses_ES
dc.identifier.pubmedID33704002es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13823
dc.language.isoenges_ES
dc.publisherTaylor & Francis
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI18/00154es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PT17/0019es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/COV20/00349es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/AC17/00019es_ES
dc.relation.publisherversionhttps://doi.org/10.1080/22221751.2021.1902755es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectGenetic variantses_ES
dc.subjectSingle-nucleotide polymorphismes_ES
dc.subjectSusceptibilityes_ES
dc.subject.meshGenetic Predisposition to Diseasees_ES
dc.subject.meshHealth Personneles_ES
dc.subject.meshPolymorphism, Single Nucleotidees_ES
dc.subject.meshSARS-CoV-2es_ES
dc.subject.meshAdultes_ES
dc.subject.meshAgedes_ES
dc.titleRole of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workerses_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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