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The circadian neutrophil, inside-out.

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dc.contributor.authorOvadia, Samuel
dc.contributor.authorÖzcan, Alaz
dc.contributor.authorHidalgo, Andres
dc.contributor.funderNational Institutes of Health (Estados Unidos)es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderFundación La Caixaes_ES
dc.contributor.funderUnión Europea. Comisión Europeaes_ES
dc.contributor.funderSwiss National Science Foundationes_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)es_ES
dc.date.accessioned2023-07-17T09:24:47Z
dc.date.available2023-07-17T09:24:47Z
dc.date.issued2023-06-01
dc.description.abstractThe circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil-circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis study has been possible through grants R01AI165661 from the National Institutes of Health, RTI2018-095497-B-I00 from Ministerio de Ciencia e Innovacion, HR17_00527 from Fundación La Caixa, and FET-OPEN (no. 861878) from the European Commission. A.O is supported by the Swiss National Science Foundation (P500PB-206852). The CNIC is supported by Ministerio de Ciencia e Innovacion and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). Conflict of interest statement. A.H. is a paid consultant for Calida Therapeutics. The other authors declare no conflict of interest.es_ES
dc.format.number6es_ES
dc.format.page555es_ES
dc.format.volume113es_ES
dc.identifier.citationJ Leukoc Biol. 2023 Jun 1;113(6):555-566es_ES
dc.identifier.doi10.1093/jleuko/qiad038es_ES
dc.identifier.e-issn1938-3673es_ES
dc.identifier.journalJournal of leukocyte biologyes_ES
dc.identifier.pubmedID36999376es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/16259
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/HR17_00527es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/CEX2020-001041-Ses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/FET-OPEN/861878es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/jleuko/qiad038es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshNeutrophilses_ES
dc.subject.meshCircadian Clockses_ES
dc.subject.meshCircadian Rhythmes_ES
dc.subject.meshHomeostasises_ES
dc.titleThe circadian neutrophil, inside-out.es_ES
dc.typereviewes_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublicationacb8e30b-34b9-4718-b517-8d5962f70950
relation.isAuthorOfPublication.latestForDiscoveryacb8e30b-34b9-4718-b517-8d5962f70950

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