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Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.

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dc.contributor.authorCordero, Alex
dc.contributor.authorSantamaría, Patricia G
dc.contributor.authorGonzález-Suárez, Eva
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)es_ES
dc.contributor.funderFundacio La Marato de TV3es_ES
dc.contributor.funderMinisterio de Ciencia y Universidades (España)es_ES
dc.date.accessioned2024-04-04T12:07:23Z
dc.date.available2024-04-04T12:07:23Z
dc.date.issued2023-02-18
dc.description.abstractDetermination of the mammary epithelial cell that serves as the cell of origin for breast cancer is key to understand tumor heterogeneity and clinical management. In this study, we aimed to decipher whether Rank expression in the presence of PyMT and Neu oncogenes might affect the cell of origin of mammary gland tumors. We observed that Rank expression in PyMT+/- and Neu+/- mammary glands alters the basal and luminal mammary cell populations already in preneoplasic tissue, which may interfere with the tumor cell of origin restricting their tumorigenesis ability upon transplantation assays. In spite of this, Rank expression eventually promotes tumor aggressiveness once tumorigenesis is established.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by grants to E. Gonzalez-Suarez SAF2014-55997-R and SAF2017-86117-R funded by MCIN/AEI/10.13039/501100011033 co-funded by FEDER funds/European Regional Developmental fund (ERDF) A way of making Europe", by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (ERC-CoG grant agreement no. 682935) and by the Fundacio La Marato de TV3 20131530. We thank CERCA Programme/Generalitat de Catalunya for institutional support. We are grateful to Amgen for providing Rank+/tg mice. We thank the IDIBELL/CNIO Animal Facilities for their assistance with mouse colonies.es_ES
dc.format.number1es_ES
dc.format.page2es_ES
dc.format.volume28es_ES
dc.identifier.citationJ Mammary Gland Biol Neoplasia . 2023 ;28(1):2es_ES
dc.identifier.doi10.1007/s10911-023-09530-4es_ES
dc.identifier.e-issn1573-7039es_ES
dc.identifier.journalJournal of mammary gland biology and neoplasiaes_ES
dc.identifier.pubmedID36808257es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/19119
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/SAF2017-86117-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/682935/EUes_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s10911-023-09530-4.es_ES
dc.repisalud.institucionCNIOes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshEctopic Gene Expressiones_ES
dc.subject.meshMammary Neoplasms, Experimentales_ES
dc.subject.meshAnimalses_ES
dc.subject.meshHumanses_ES
dc.subject.meshMicees_ES
dc.subject.meshCarcinogenesises_ES
dc.subject.meshEpithelial Cellses_ES
dc.subject.meshOncogeneses_ES
dc.subject.meshMice, Transgenices_ES
dc.titleRank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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