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Clinical significance of asymptomatic Leishmania infantum infection in people living with HIV_data set

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dc.contributor.authorBarbiero, Anna
dc.contributor.authorMoreno, Javier
dc.contributor.authorBernardo, Lorena
dc.contributor.authorLozano-Rendal, Marina
dc.contributor.authorSolana, Jose Carlos
dc.contributor.authorSanchez Herrero, Carmen
dc.contributor.authorMarco Vinuesa, Arantxa
dc.contributor.authorCuenca, Paula
dc.contributor.authorSan Martín, Juan Víctor
dc.contributor.authorLagi, Filippo
dc.contributor.authorZammarchi, Lorenzo
dc.contributor.authorSpinicci, Michele
dc.contributor.authorBartoloni, Alessandro
dc.contributor.authorGranozzi, Bianca
dc.contributor.authorBacchiega, Michele
dc.contributor.authorDe Pascali, Alessandra Mistral
dc.contributor.authorBalducelli, Emma
dc.contributor.authorOrtalli, Margherita
dc.contributor.authorZaghi, Irene
dc.contributor.authorVarani, Stefania
dc.contributor.authorCarrillo, Eugenia
dc.coverage.spatialSpain (Madrid, Fuenlabrada and Majadahonda)
dc.coverage.spatialItaly (Florence and Bologna)
dc.coverage.temporal01/09/2013 - 30/04/2023
dc.coverage.temporal12/2025 (Clinical follow-up data)
dc.date.accessioned2026-09-15T12:18:20Z
dc.date.available2026-09-15T12:18:20Z
dc.date.issued2026-09-10
dc.descriptionAmong 204 people living with HIV receiving effective antiretroviral therapy in Leishmania infantum-endemic areas of Spain and Italy, asymptomatic Leishmania infection was detected in 26.5% of participants. The whole blood stimulation assay was the most sensitive individual test, while its combination with ELISA showed the highest diagnostic sensitivity. Despite the relatively high prevalence of asymptomatic infection, no participants progressed to visceral leishmaniasis during a median follow-up of 5.8 years. These findings suggest that, in virologically controlled PLWH on continuous ART, asymptomatic L. infantum infection has limited prognostic significance and supports clinical monitoring rather than routine screening or pre-emptive treatment.
dc.description.abstractThis dataset contains demographic, clinical, immunological and molecular data from 204 people living with HIV (PLWH) recruited between 2013 and 2023 in Spain and Italy, all residing in Leishmania infantum-endemic areas. For each participant, the database includes age, sex, birthplace, cohort, CD4+ T-cell count, HIV viral load, antiretroviral treatment information, and the results of three complementary screening methods for asymptomatic Leishmania infection: kDNA real-time PCR, ELISA serology, and a whole blood stimulation assay (WBA) measuring parasite-specific cytokine responses (IFN-γ, IL-2 and IP-10). In addition, the dataset contains follow-up information for individuals with positive screening results, including repeated PCR, serological and immunological assessments and clinical monitoring for progression to visceral leishmaniasis. No cases of progression to overt VL were recorded during follow-up.
dc.description.peerreviewedNo
dc.description.sponsorshipThis study was conducted within collaborative research activities on leishmaniasis involving the Instituto de Salud Carlos III (Spain), University of Bologna (Italy), and University of Florence (Italy).
dc.identifier.citationCarrillo, Eugenia... [et al.]. Clinical significance of asymptomatic Leishmania infantum infection in people living with HIV [Dataset], Versión de septiembre de 2026. Repositorio Institucional de Salud REPISALUD. https://doi.org/10.4321/repisalud.27716.
dc.identifier.doi10.4321/repisalud.27716
dc.identifier.urihttps://hdl.handle.net/20.500.12105/27716
dc.language.isoeng
dc.publication.year2026
dc.publisherInstituto de Salud Carlos III (ISCIII). Centro Nacional de Microbiología (CNM)
dc.relation.requiresSTATA version 19.5 (StataCorp, College Station, TX, USA).
dc.repisalud.centroISCIII::Centro Nacional de Microbiología (CNM)
dc.repisalud.institucionISCIII
dc.rights.accessRightsopen access
dc.rights.licenseAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHIV
dc.subjectAIDS
dc.subjectLeishmania infantum
dc.subjectAsymptomatic infection
dc.subjectSurveillance
dc.subjectVisceral leishmaniasis
dc.subjectWhole blood stimulation assay
dc.subjectELISA
dc.subjectPCR
dc.subjectImmunocompromised patients
dc.subjectSouthern Europe
dc.titleClinical significance of asymptomatic Leishmania infantum infection in people living with HIV_data set
dc.typedataset
dspace.entity.typePublication
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