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The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells

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dc.contributor.authorVillanueva, Andrea A
dc.contributor.authorPuvogel, Sofía
dc.contributor.authorLois, Pablo
dc.contributor.authorMuñoz-Palma, Ernesto
dc.contributor.authorRamírez Orellana, Manuel
dc.contributor.authorLubieniecki, Fabiana
dc.contributor.authorCasco Claro, Fernando
dc.contributor.authorGallegos, Iván
dc.contributor.authorGarcia-Castro, Javier
dc.contributor.authorSánchez-Gómez, Pilar
dc.contributor.authorTorres, Vicente A
dc.contributor.authorPalma, Verónica
dc.contributor.funderFondo Nacional de Desarrollo Científico y Tecnológico (Chile)
dc.contributor.funderComisión Nacional de Investigación Científica y Tecnológica (Chile)
dc.date.accessioned2019-07-11T10:38:40Z
dc.date.available2019-07-11T10:38:40Z
dc.date.issued2018
dc.description.abstractNeuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work was supported by: FONDECYT 1140697 (VP), 1180495 (VT); CONICYT Fellowships for PhD studies [21130521] (AV).es_ES
dc.format.number1es_ES
dc.format.page40es_ES
dc.format.volume13es_ES
dc.identifier.citationCell Adh Migr. 2019 Dec;13(1):33-40es_ES
dc.identifier.doi10.1080/19336918.2018.1506652es_ES
dc.identifier.e-issn1933-6926es_ES
dc.identifier.issn1933-6918es_ES
dc.identifier.journalCell Adhesion & Migrationes_ES
dc.identifier.pubmedID30160193es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7895
dc.language.isoenges_ES
dc.publisherTaylor & Francis
dc.relation.publisherversionhttps://doi.org/10.1080/19336918.2018.1506652es_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLaminin γ1es_ES
dc.subjectNeogenin-1es_ES
dc.subjectNetrin-4es_ES
dc.subjectNeuroblastomaes_ES
dc.subjectBasal laminaes_ES
dc.subjectCell adhesiones_ES
dc.subjectCell migrationes_ES
dc.titleThe Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cellses_ES
dc.typeresearch articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
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