Publication: Parkinson's Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline
dc.contributor.author | Ayala, Alba | |
dc.contributor.author | Triviño-Juárez, José Matías | |
dc.contributor.author | Forjaz, Maria João | |
dc.contributor.author | Rodríguez-Blázquez, Carmen | |
dc.contributor.author | Rojo-Abuin, Jose Manuel | |
dc.contributor.author | Martínez-Martín, Pablo | |
dc.contributor.author | ELEP Project | |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.date.accessioned | 2022-05-25T10:36:02Z | |
dc.date.available | 2022-05-25T10:36:02Z | |
dc.date.issued | 2017-10-30 | |
dc.description.abstract | Objective: The aim of this study is to present a predictive model of Parkinson's disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD). Methods: This is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years. Results: The clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable. Conclusion: Disease progression depends more on the individual's baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease. | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.description.sponsorship | The Spanish Longitudinal PD Patient Study (Estudio longitudinal de pacientes con enfermedad de Parkinson) was supported by an Intramural Research Programme grant from the Carlos III Institute of Health (Code: EPY1271/05). Partial funding was also obtained from the following grants: ENVACES (MINECO/FEDER/UE, ref. CSO2015-64115-R) and ENCAGE-CM (Comunidad de Madrid, ref. S2015/HUM-3367). | es_ES |
dc.format.page | 551 | es_ES |
dc.format.volume | 8 | es_ES |
dc.identifier.citation | Front Neurol. 2017 Oct 30;8:551. | es_ES |
dc.identifier.doi | 10.3389/fneur.2017.00551 | es_ES |
dc.identifier.issn | 1664-2295 | es_ES |
dc.identifier.journal | Frontiers in Neurology | es_ES |
dc.identifier.pubmedID | 29163328 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14523 | |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//CSO2015-64115-R/ES/LA CONSTRUCCION DEL ENVEJECIMIENTO ACTIVO EN ESPAÑA: AUTOVALORACION, DETERMINANTES Y EXPECTATIVAS DE CALIDAD DE VIDA/ | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/EPY1271/05 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fneur.2017.00551 | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.centro | ISCIII::Escuela Nacional de Sanidad | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Parkinson’s disease | es_ES |
dc.subject | Disease global severity | es_ES |
dc.subject | Multilevel analysis | es_ES |
dc.subject | Multiple imputation | es_ES |
dc.subject | Predictive model | es_ES |
dc.title | Parkinson's Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline | es_ES |
dc.type | journal article | es_ES |
dc.type.hasVersion | VoR | es_ES |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 88f80e70-adbb-4a33-8f2f-3ca9e26b356a | |
relation.isAuthorOfPublication | 16cb2ba7-777d-4912-ac39-11335a3dd901 | |
relation.isAuthorOfPublication | a0911756-32d0-4d9b-8e11-3140646980a3 | |
relation.isAuthorOfPublication.latestForDiscovery | 88f80e70-adbb-4a33-8f2f-3ca9e26b356a |
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