Publication:
Role of Neutralizing Antibodies in CMV Infection: Implications for New Therapeutic Approaches

Simple item page
dc.contributor.authorSandonís, Virginia
dc.contributor.authorGarcia-Rios, Estefani
dc.contributor.authorMcConnell, Michael J
dc.contributor.authorPerez-Romero, Pilar
dc.contributor.funderInstituto de Salud Carlos III
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderRETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.date.accessioned2021-01-27T08:33:54Z
dc.date.available2021-01-27T08:33:54Z
dc.date.issued2020-11
dc.description.abstractCytomegalovirus (CMV) infection elicits a potent immune response that includes the stimulation of antibodies with neutralizing activity. Recent studies have focused on elucidating the role of neutralizing antibodies in protecting against CMV infection and disease and characterizing viral antigens against which neutralizing antibodies are directed. Here, we provide a synthesis of recent data regarding the role of neutralizing antibodies in protection against CMV infection/disease. We consider the role of humoral immunity in the context of the global CMV-specific immune response, and the implications that recent findings have for vaccine and antibody-based therapy design.es_ES
dc.description.peerreviewedSies_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Science, Innovation and University, Instituto de Salud Carlos III Grant/ Award Numbers: PI17CIII-00014 (MPY110/18); DTS18CIII/00006 (MPY127/19). This work was supported by Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministry of Science, Innovation and University, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0009), cofinanced by European Development Regional Fund ‘A way to achieve Europe’. E.G.-R. is supported by the Sara Borrell Program (CD18CIII/00007), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades.es_ES
dc.format.number11es_ES
dc.format.page900-912es_ES
dc.format.volume28es_ES
dc.identifier.citationTrends Microbiol. 2020 Nov;28(11):900-912.es_ES
dc.identifier.doi10.1016/j.tim.2020.04.003es_ES
dc.identifier.e-issn1878-4380es_ES
dc.identifier.journalTrends in microbiologyes_ES
dc.identifier.pubmedID32448762es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11680
dc.language.isoenges_ES
dc.publisherCell Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17CIII-00014 (MPY110/18)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/DTS18CIII/00006 (MPY127/19)es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/REIPI RD16/0016/0009es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD18CIII/00007es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.tim.2020.04.003es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCMV-specific immune responsees_ES
dc.subjectAntibody-based therapeuticses_ES
dc.subjectCytomegaloviruses_ES
dc.subjectNeutralizing antibodieses_ES
dc.subjectVaccine designes_ES
dc.titleRole of Neutralizing Antibodies in CMV Infection: Implications for New Therapeutic Approacheses_ES
dc.typeresearch articlees_ES
dc.type.hasVersionSMURes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication50b540df-28b6-4182-a1ee-d7ee50b0114e
relation.isAuthorOfPublication1d2e9ea7-be75-4b13-a09e-656f8f304a14
relation.isAuthorOfPublication619c44d6-0adf-4ccf-9b6a-66663bad5429
relation.isAuthorOfPublication.latestForDiscovery50b540df-28b6-4182-a1ee-d7ee50b0114e
relation.isFunderOfPublication7d739953-4b68-4675-b5bb-387a9ab74b66
relation.isFunderOfPublication1aef4c3b-1ee5-4534-83b4-3f3811c67280
relation.isFunderOfPublication59c823cb-42b5-4b1b-a401-bf53ee82c170
relation.isFunderOfPublicationefa64f05-b985-4984-8f1e-5fc4ef21f502
relation.isFunderOfPublication.latestForDiscovery7d739953-4b68-4675-b5bb-387a9ab74b66
relation.isPublisherOfPublicationaea619d1-42a6-47f8-84e2-6bc27d6f8300
relation.isPublisherOfPublication.latestForDiscoveryaea619d1-42a6-47f8-84e2-6bc27d6f8300

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
RoleOfNeutralizingAntibodies_2020.pdf
Size:
716.63 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Centro Nacional de Microbiología (CNM)
i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)