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IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected patients

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dc.contributor.authorJimenez-Sousa, Maria Angeles
dc.contributor.authorBerenguer, J
dc.contributor.authorFernandez-Rodriguez, Amanda
dc.contributor.authorMicheloud, D
dc.contributor.authorGuzman-Fulgencio, Maria
dc.contributor.authorMiralles, P
dc.contributor.authorPineda-Tenor, Daniel
dc.contributor.authorGarcia-Alvarez, Monica
dc.contributor.authorLópez, J C
dc.contributor.authorAldámiz-Echevarria, T
dc.contributor.authorCarrero, A
dc.contributor.authorResino, Salvador
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderRETICS-Sida (RIS-ISCIII) (España)es_ES
dc.contributor.funderFundación para la Investigación y la Prevención del Sida en Españaes_ES
dc.date.accessioned2024-01-19T12:50:47Z
dc.date.available2024-01-19T12:50:47Z
dc.date.issued2014-03
dc.description.abstractHepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV-coinfected patients. We carried out a cross-sectional study on 203 patients. IL28B (rs8099917) and IL28RA (rs10903035) polymorphisms were genotyped by GoldenGate(®) assay. IR was defined as homeostatic model assessment (HOMA) values ≥3.00. Univariate and multivariate generalized linear models (GLM) were used to compare HOMA values and the percentage of patients with IR according to IL28B and IL28RA genotypes. In total, 32% (n = 65/203) of the patients had IR. IL28B rs8099917 TT was not significantly associated with HOMA values and IR. In contrast, rs10903035 AA was significantly associated with high HOMA values taking into account all patients (P = 0.024), as well as the subgroups of patients with significant fibrosis (P = 0.047) and infected with HCV genotype 3 (P = 0.024). Additionally, rs10903035 AA was significantly associated with IR (HOMA ≥3.00) in all patients (adjusted odds ratio (aOR) = 2.02; P = 0.034), in patients with significant fibrosis (aOR = 2.86; P = 0.039) and HCV genotype 3 patients (aOR = 4.89; P = 0.031). In conclusions, IL28RA polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR, but this association was different depending on hepatic fibrosis and HCV genotype.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipThis work has been supported by grants given by Fondo de Investigación de Sanidad en España (FIS) [Spanish Health Founds for Research] [grant numbers PI08/0738, PI11/00245; PI08/0928, and PI11/01556], Red Española de Investigación en SIDA (RIS) [AIDS Research Network] [grant numbers RD12/0017/0024 and RD12/0017/0004]and ‘Fundación para la Investigación y la Prevención del Sida en España’ (FIPSE) [grant number 361020/10]. AFR,MGF, MGA, DPT and MAJS are supported by ‘Instituto de Salud Carlos III’ [grant numbers PI11/00245, CM09/00031, CD12/00442, CM12/00043 and CM10/00105, respectively]es_ES
dc.format.number3es_ES
dc.format.page189-197es_ES
dc.format.volume21es_ES
dc.identifier.citationJ Viral Hepat. 2014 Mar;21(3):189-97.es_ES
dc.identifier.e-issn1365-2893es_ES
dc.identifier.journalJournal of viral hepatitises_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/17236
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MICINN//PI11%2F00245/ES/Erradicación del VHC en pacientes coinfectados por VIH%2FVHC: efectos sobre la inflamación, el daño endotelial, la activación inmune y la aterosclerosis preclínica/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MICINN//PI11%2F01556/ES/Erradicación del VHC en pacientes coinfectados por VIH%2FVHC: efectos sobre la inflamación, el daño endotelial, la activación inmune y la aterosclerosis preclínica/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MINECO//RD12%2F0017%2F0024/ES/SIDA/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MINECO//RD12%2F0017%2F0004/ES/SIDA/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MICINN//CM09%2F00031/ES/CM09%2F00031/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MINECO//CD12%2F00442/ES/CD12%2F00442/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MINECO//CM12%2F00043/ES/CM12%2F00043/es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/MICINN//CM10%2F00105/ES/CM10%2F00105/es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI08/0738es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI08/0928es_ES
dc.relation.publisherversionhttps://doi.org/10.1111/jvh.12130es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAIDSes_ES
dc.subjectHepatitis Ces_ES
dc.subjectInsulin resistancees_ES
dc.subjectLiver fibrosises_ES
dc.subjectSNPses_ES
dc.subject.meshCoinfectiones_ES
dc.subject.meshPolymorphism, Genetices_ES
dc.subject.meshAdultes_ES
dc.subject.meshCD4 Lymphocyte Countes_ES
dc.subject.meshCross-Sectional Studieses_ES
dc.subject.meshFemalees_ES
dc.subject.meshGenetic Association Studieses_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHIV Infectionses_ES
dc.subject.meshHIV-1es_ES
dc.subject.meshHepaciviruses_ES
dc.subject.meshHepatitis C, Chronices_ES
dc.subject.meshHumanses_ES
dc.subject.meshInsulin Resistancees_ES
dc.subject.meshInterferonses_ES
dc.subject.meshInterleukinses_ES
dc.subject.meshMalees_ES
dc.subject.meshOdds Ratioes_ES
dc.subject.meshReceptors, Cytokinees_ES
dc.subject.meshViral Loades_ES
dc.titleIL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected patientses_ES
dc.typeresearch articlees_ES
dc.type.hasVersionAMes_ES
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery2bf7faec-7f00-44ba-9494-efb396305551
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