Publication:
4D reconstruction of murine developmental trajectories using spherical harmonics.

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dc.contributor.authorDalmasso, Giovanni
dc.contributor.authorMusy, Marco
dc.contributor.authorNiksic, Martina
dc.contributor.authorRobert-Moreno, Alexandre
dc.contributor.authorBadia-Careaga, Claudio
dc.contributor.authorSanz-Ezquerro, Juan Jose
dc.contributor.authorSharpe, James
dc.contributor.funderEuropean Molecular Biology Laboratoryes_ES
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC)es_ES
dc.contributor.funderFundación La Marató TV3es_ES
dc.date.accessioned2023-04-12T10:35:28Z
dc.date.available2023-04-12T10:35:28Z
dc.date.issued2022-09-12
dc.description.abstractNormal organogenesis cannot be recapitulated in vitro for mammalian organs, unlike in species including Drosophila and zebrafish. Available 3D data in the form of ex vivo images only provide discrete snapshots of the development of an organ morphology. Here, we propose a computer-based approach to recreate its continuous evolution in time and space from a set of 3D volumetric images. Our method is based on the remapping of shape data into the space of the coefficients of a spherical harmonics expansion where a smooth interpolation over time is simpler. We tested our approach on mouse limb buds and embryonic hearts. A key advantage of this method is that the resulting 4D trajectory can take advantage of all the available data while also being able to interpolate well through time intervals for which there are little or no data. This allows for a quantitative, data-driven 4D description of mouse limb morphogenesis.es_ES
dc.description.peerreviewedSíes_ES
dc.description.sponsorshipWe thank Isaac Esteban and Miguel Torres for their invaluable discussions on shape comparison and spherical harmonics; Antoni Matyjaszkiewicz for his help with the webpage of the project; Isabel Romero Calvo for her precious suggestions on the graphical abstract and Carla Manzanas for the media coverage. This research was supported by core funding from EMBL and CRG, and also the ERC advanced grant SIMBIONT (project no. 670555) and a grant from the Fundacion La Marato TV3 (grant 082030). G.D. and M.M. were supported by the ERC advanced grant SIMBIONT (project no. 670555).es_ES
dc.format.number17es_ES
dc.format.page2140es_ES
dc.format.volume57es_ES
dc.identifier.citationDev Cell. 2022 Sep 12;57(17):2140-2150.e5es_ES
dc.identifier.doi10.1016/j.devcel.2022.08.005es_ES
dc.identifier.e-issn1878-1551es_ES
dc.identifier.journalDevelopmental celles_ES
dc.identifier.pubmedID36055247es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15784
dc.language.isoenges_ES
dc.publisherCell Presses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/082030es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ERC/670555es_ES
dc.relation.publisherversion10.1016/j.devcel.2022.08.005es_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genómica Funcionales_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Medicina Comparativaes_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshImaging, Three-Dimensionales_ES
dc.subject.meshOrganogenesises_ES
dc.subject.meshAlgorithmses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshMammalses_ES
dc.subject.meshMicees_ES
dc.title4D reconstruction of murine developmental trajectories using spherical harmonics.es_ES
dc.typejournal articlees_ES
dc.type.hasVersionVoRes_ES
dspace.entity.typePublication
relation.isAuthorOfPublication426f4110-ee77-4281-ba5c-016002b9adc9
relation.isAuthorOfPublication.latestForDiscovery426f4110-ee77-4281-ba5c-016002b9adc9
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